About: P38 mitogen-activated protein kinases

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p38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy. Persistent activation of the p38 MAPK pathway in muscle satellite cells (muscle stem cells) due to ageing, impairs muscle regeneration.

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rdf:type	Thing Biomolecule Biomolecule Protein yago:Abstraction100002137 yago:Chemical114806838 yago:Compound114818238 yago:Group100031264 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 protein yago:Substance100019613 yago:Thing100002452 yago:Unit109465459 yago:WikicatProteinGroups umbel-rc:ProteinMolecule
rdfs:label	P38 MAPK (ca) P38-mitogenaktivierte Proteinkinasen (de) P38分裂促進因子活性化タンパク質キナーゼ (ja) P38 mitogen-activated protein kinases (en)
rdfs:comment	p38-mitogenaktivierte Proteinkinasen (p38 MAPK) sind eine Klasse von Proteinen und gehören wie die JNK zur Familie der (MAPK). Sie sind in Signalkaskaden (siehe eingehend unter MAP-Kinase-Weg) eingebunden, deren Auslöser externe Stimuli wie Cytokine, Hitzeschock, Strahlung und osmotischen Schock sind. Sie haben darüber Bedeutung für Zelldifferenzierung, Zellwachstum und Apoptose. Von der p38-MAP-Kinase sind beim Menschen vier paraloge Isoformen bekannt, die p38-α(MAPK14), -β(MAPK11), -γ(MAPK12 oder ERK6) und -δ(MAPK13 oder SAPK4). (de) p38 MAPK conformen una família de proteïnes cinases activades per mitogens, sensibles a estímuls d'estrès i tensions ambientals com ara les citocines, la radiació ultraviolada, el xoc tèrmic i el xoc osmòtic. Estan involucrades en la diferenciació cel·lular, l'apoptosi i l'autofàgia, entre altres processos. Les proteïnes cinases activades per mitogens formen part del grup de cinases intracel·lulars diana de diversos estímuls extracel·lulars i són, conseqüentment, reguladores d'un elevat nombre de processos i funcions cel·lulars. (ca) p38 mitogen-activated protein kinases are a class of mitogen-activated protein kinases (MAPKs) that are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock, and are involved in cell differentiation, apoptosis and autophagy. Persistent activation of the p38 MAPK pathway in muscle satellite cells (muscle stem cells) due to ageing, impairs muscle regeneration. (en) p38分裂促進因子活性化タンパク質キナーゼ（p38ぶんれつそくしんいんしかっせいかタンパクしつキナーゼ、英語: p38 mitogen-activated protein kinases）は、サイトカインや紫外線照射、熱ショック、浸透圧ショックといったストレス刺激に応答する分裂促進因子活性化タンパク質キナーゼ（MAPキナーゼ）の一分類であり、細胞の分化、アポトーシス、オートファジーに関与している。 p38 MAPキナーゼ（MAPK）は、RKあるいはCSBP（サイトカイニン特異的結合タンパク質）とも呼ばれ、酵母においてサイトカインやストレスに対する細胞応答を制御するシグナル伝達に関与しているMAPキナーゼのほ乳類オーソログである。 p38-α、-β、-γ ( / ERK6)、-δ ( / SAPK4) の4種のp38 MAPキナーゼが同定されている。SAPK/JNK経路と同様に、p38 MAPキナーゼは浸透圧ショック、炎症性サイトカイン、リポ多糖 (LPS)、紫外線、成長因子を含む様々な細胞ストレスによって活性化される。 (ja)
foaf:name	mitogen-activated protein kinase 11 (en) mitogen-activated protein kinase 12 (en) mitogen-activated protein kinase 13 (en) mitogen-activated protein kinase 14 (en)
name	MAPK11 MAPK12 MAPK13 MAPK1
dct:subject	EC 2.7.11 Protein kinases
Wikipage page ID	7337013 (xsd:integer)
Wikipage revision ID	1116923560 (xsd:integer)
Link from a Wikipage to another Wikipage	MAPK11 MAPK12 MAPK13 MAPK1 MAPKAPK2 DUX4 dbr:P53 EC 2.7.11 Chronic obstructive pulmonary disease Apoptosis Losmapimod Stem cell Ageing Threonine Tyrosine Cytokines Facioscapulohumeral muscular dystrophy Osmotic Growth factors Protein kinases Yeast Mitogen-activated protein kinase Autophagy C-Jun N-terminal kinases Ultraviolet Lipopolysaccharides Myosatellite cell Oncogene Phosphorylation MEF2 ZFP36 Orthologue ATF2 MKK3 dbr:Pamapimod dbr:Hog1p dbr:Mac_(gene) dbr:PH-797804 dbr:SEK_(gene)
Link from a Wikipage to an external page	http://www.mapkinases.eu https://web.archive.org/web/20210415072533/http:/www.mapkinases.eu/ http://www.novusbio.com/p38mapkpathway.html https://web.archive.org/web/20090428134949/http:/www.sabiosciences.com/pathway.php%3Fsn=P38_Signaling http://www.biocarta.com/pathfiles/m_p38mapkPathway.asp
sameAs	P38 mitogen-activated protein kinases P38 mitogen-activated protein kinases P38 mitogen-activated protein kinases P38 mitogen-activated protein kinases P38 mitogen-activated protein kinases P38 mitogen-activated protein kinases P38 mitogen-activated protein kinases P38 mitogen-activated protein kinases
dbp:wikiPageUsesTemplate	dbt:2.7-enzyme-stub dbt:Enzymes dbt:Main dbt:MeshName dbt:Portal_bar

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