About: Otilonium bromide

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An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.org associated with source document(s)

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Otilonium bromide, sold under the trade name Spasmomen among others, is an antimuscarinic and calcium channel blocker used to relieve spasmodic pain of the gut, especially in irritable bowel syndrome.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Pill (pharmacy) yago:WikicatBenzoates yago:WikicatBromides yago:WikicatMolecularFormulas yago:Abstraction100002137 yago:Benzoate114775067 yago:Bromide114785625 yago:Chemical114806838 yago:Communication100033020 yago:Compound114818238 yago:Element114840755 yago:Ester114850483 yago:Formula106816935 yago:Halide114904359 yago:Material114580897 yago:Matter100020827 yago:Message106598915 yago:MolecularFormula106817173 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalEntity100001930 yago:QuaternaryAmmoniumCompound114691231 yago:Quintessence114847103 yago:Relation100031921 drug yago:Salt115010703 yago:Statement106722453 yago:Substance100019613 yago:WikicatEsters yago:WikicatEthers yago:WikicatPhenolEthers yago:WikicatQuaternaryAmmoniumCompounds umbel-rc:DrugProduct
rdfs:label	أوتيلونيوم برومايد (ar) Bromuro de otilonio (es) Bromure d'otilonium (fr) Otilonio bromuro (it) Otilonium bromide (en)
rdfs:comment	أوتيلونيوم برومايد (Otilonium bromide) مضاد مسكاريني، يستخدم لعلاج تشنج السبيل الهضمي. (ar) El bromuro de otilonio es un antimuscarínico y bloqueador de los canales de calcio utilizado para aliviar los dolores abdominales espasmódicos, especialmente en casos de síndrome del intestino irritable. (es) Otilonium bromide, sold under the trade name Spasmomen among others, is an antimuscarinic and calcium channel blocker used to relieve spasmodic pain of the gut, especially in irritable bowel syndrome. (en) L'otilonio bromuro è un sale (bromuro) di ammonio quaternario. È un agente spasmolitico, particolarmente attivo sulla muscolatura liscia del tubo digerente. La sostanza è un principio attivo usato come antispasmodico intestinale, il cui meccanismo di azione ancora non è totalmente compreso in base a quanto riportato nella letteratura medica. In Italia il farmaco è venduto dalla società farmaceutica Menarini con il nome commerciale di Spasmomen, nella forma farmaceutica di confetti. Viene inoltre commercializzato dalla medesima società anche come associazione precostituita otilonio bromuro e diazepam con il nome di Spasmomen somatico. (it) Le bromure d'otilonium est un dérivé ammonium quaternaire et un anticholinergique synthétique, spasmolytique musculotrope efficace, doté d'un puissant pouvoir antispasmodique sélectif sur la musculature lisse de l'appareil digestif dû à l’interférence avec la mobilisation des ions calcium tant intra- qu'extra-cellulaires. Il fonctionne grâce à la suppression des contractions induites par les tachykinines et ainsi modulation de la douleur, par la liaison du bromure d'otilonium aux récepteurs de tachykinines. Il possède une action antagoniste au niveau de récepteurs muscariniques très spécifiques, sans causer d'effets antimuscariniques systémiques. L'activité spasmolytique locale de l'otilonium dans le tractus digestif se manifeste à des doses qui n'induisent pas d'effets atropiniques systém (fr)
foaf:depiction
dcterms:subject	Benzanilides Phenol ethers 4-Aminobenzoate esters Muscarinic antagonists Quaternary ammonium compounds Bromides
Wikipage page ID	19926385 (xsd:integer)
Wikipage revision ID	1076600146 (xsd:integer)
Link from a Wikipage to another Wikipage	Benzanilides Antimuscarinic Phenol ethers 4-Aminobenzoate esters Calcium channel Calcium channel blocker Irritable bowel syndrome Muscarinic antagonists Quaternary ammonium compounds Bromides Muscarinic receptor NK2 receptor
sameAs	Otilonium bromide Otilonium bromide Otilonium bromide Otilonium bromide Otilonium bromide Otilonium bromide Otilonium bromide Otilonium bromide Otilonium bromide Otilonium bromide Otilonium bromide Otilonium bromide Otilonium bromide Otilonium bromide
dbp:wikiPageUsesTemplate	dbt:Gastrointestinal-drug-stub dbt:Drugbox dbt:More_citations_needed dbt:Multiple_issues dbt:Reflist dbt:Short_description dbt:Cascite dbt:Chemspidercite dbt:Context dbt:Drugbankcite dbt:Fdacite dbt:Keggcite dbt:Stdinchicite dbt:Drugs_for_functional_gastrointestinal_disorders dbt:Drugs.com dbt:Muscarinic_acetylcholine_receptor_modulators
thumbnail	wiki-commons:Special:FilePath/Otilonium_bromide.png?width=300
ATC suffix	AB06 (en)
br	1 (xsd:integer)

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