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About: Ornithine decarboxylase antizyme     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatProteinFamilies, within Data Space : dbpedia.org associated with source document(s)

Type: ThingBiomoleculeBiomoleculeProteinyago:Abstraction100002137yago:Family108078020yago:Group100031264yago:Organization108008335yago:YagoLegalActoryago:YagoLegalActorGeoyago:YagoPermanentlyLocatedEntitydrugproteinyago:SocialGroup107950920yago:Unit108189659yago:WikicatProteinFamilies New Facet based on Instances of this Class

In molecular biology, Ornithine decarboxylase antizyme (ODC-AZ) is an ornithine decarboxylase inhibitor. It binds to, and destabilises, ornithine decarboxylase (ODC), a key enzyme in polyamine synthesis. ODC is then rapidly degraded. It was first characterized in 1981. The expression of ODC-AZ requires programmed, ribosomal frameshifting which is modulated according to the cellular concentration of polyamines. High levels of polyamines induce a +1 ribosomal frameshift in the translation of mRNA for the antizyme leading to the expression of a full-length protein. At least two forms of ODC-AZ exist in mammals and the protein has been found in Drosophila (protein Gutfeeling) as well as in Saccharomyces yeast (encoded by the OAZ1 gene).