State Route 125 (SR 125) is an east–west state highway in the southwestern portion of the U.S. state of Ohio. Its western terminus is within the Cincinnati city limits, about 5 miles (8.0 km) east of downtown, at U.S. Route 50 – this is also the western terminus of State Route 32 and the southern terminus of State Route 561. The route’s eastern terminus is at U.S. Route 52 approximately 7 miles (11 km) west of Portsmouth near the village of Friendship. See also National Scenic Byway, , and Shawnee State Forest and Park map