Oberwesel station is on the West Rhine Railway (German: Linke Rheinstrecke) between Koblenz and Mainz in the UNESCO World Heritage Site of the Upper Middle Rhine Valley in the German state of Rhineland-Palatinate. The station is classified by Deutsche Bahn as a category 5 station. It is in the southern part of the town of Oberwesel and is served by Regional-Express services operated by Deutsche Bahn and Regionalbahn trains operated by .