New York State Route 160 (NY 160) is a 6.58-mile-long (10.59 km) north–south state highway mostly located within Schenectady County, New York, in the United States. The southern terminus of the route is at an intersection with NY 159 in the Duanesburg hamlet of Mariaville Lake. Its northern terminus is at a junction with NY 5S in the Rotterdam hamlet of Pattersonville. While its termini are both in Schenectady County, it briefly passes into Montgomery County near its midpoint.