New York State Route 157 (NY 157) is a state highway in Albany County, New York, in the United States. It runs from an intersection with NY 156 near the hamlet of Berne to a junction with NY 85 in the hamlet of New Salem. NY 157 is a two-lane, narrow, winding route that runs along an escarpment overlooking the Capital District. The route provides access to John Boyd Thacher State Park and Thompson's Lake State Park. NY 157 was assigned to its current alignment as part of the 1930 renumbering of state highways in New York.