Naphthomycin A is a type of naphthomycin. It was isolated as a yellow pigment from Streptomyces collinus and it shows antibacterial, antifungal, and antitumor activities. Naphthomycins have the longest ansa aliphatic carbon chain of the ansamycin family. Biosynthetic origins of the carbon skeleton from PKS1 were investigated by feeding 13C-labeled precursors and subsequent 13C-NMR product analysis. Naphthomycin gene clusters have been cloned and sequenced to confirm involvement in biosynthesis via deletion of a 7.2kb region. Thirty-two genes were identified in the 106kb cluster.
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| - نفثوميسين أ (ar)
- Naftomicina A (it)
- Naphthomycin A (en)
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| - النفثوميسين أ هو نوع من النافثوميسين . تم عزله كصباغ أصفر من بكتيريا Streptomyces collinus ويظهر نشاطًا مضادًا للبكتيريا والفطريات والأورام. يحتوي النفثوميسين على أطول سلسلة كربونية أليفاتية من عائلة أنساميسين. تم التحقيق في أصول التخليق الحيوي للهيكل العظمي الكربوني من PKS1 عن طريق تغذية السلائف التي تحمل علامة 13C وتحليل المنتج اللاحق 13C-NMR. تم استنساخ مجموعات جينات النفثوميسين وتسلسلها لتأكيد المشاركة في التخليق الحيوي عن طريق حذف منطقة 7.2 كيلوبايت. تم تحديد 32 جينًا في الكتلة 106 كيلو بايت. (ar)
- Naphthomycin A is a type of naphthomycin. It was isolated as a yellow pigment from Streptomyces collinus and it shows antibacterial, antifungal, and antitumor activities. Naphthomycins have the longest ansa aliphatic carbon chain of the ansamycin family. Biosynthetic origins of the carbon skeleton from PKS1 were investigated by feeding 13C-labeled precursors and subsequent 13C-NMR product analysis. Naphthomycin gene clusters have been cloned and sequenced to confirm involvement in biosynthesis via deletion of a 7.2kb region. Thirty-two genes were identified in the 106kb cluster. (en)
- La naftomicina A è una molecola isolata sotto forma di pigmento giallo da Streptomyces collinus e mostra attività antibatteriche, antimicotiche e antitumorali. Le naftomicine rappresentano la famiglia di molecole con la catena di carbonio ansa-alifatica più lunga tra le ansamicine. Le origini biosintetiche dello scheletro carbonioso sono state studiate sfruttando l'enzima polichetide sintasi (PKS1) attraverso l'uso di precursori marcati con 13C e successiva analisi del prodotto tramite 13C-NMR. (it)
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| - النفثوميسين أ هو نوع من النافثوميسين . تم عزله كصباغ أصفر من بكتيريا Streptomyces collinus ويظهر نشاطًا مضادًا للبكتيريا والفطريات والأورام. يحتوي النفثوميسين على أطول سلسلة كربونية أليفاتية من عائلة أنساميسين. تم التحقيق في أصول التخليق الحيوي للهيكل العظمي الكربوني من PKS1 عن طريق تغذية السلائف التي تحمل علامة 13C وتحليل المنتج اللاحق 13C-NMR. تم استنساخ مجموعات جينات النفثوميسين وتسلسلها لتأكيد المشاركة في التخليق الحيوي عن طريق حذف منطقة 7.2 كيلوبايت. تم تحديد 32 جينًا في الكتلة 106 كيلو بايت. (ar)
- Naphthomycin A is a type of naphthomycin. It was isolated as a yellow pigment from Streptomyces collinus and it shows antibacterial, antifungal, and antitumor activities. Naphthomycins have the longest ansa aliphatic carbon chain of the ansamycin family. Biosynthetic origins of the carbon skeleton from PKS1 were investigated by feeding 13C-labeled precursors and subsequent 13C-NMR product analysis. Naphthomycin gene clusters have been cloned and sequenced to confirm involvement in biosynthesis via deletion of a 7.2kb region. Thirty-two genes were identified in the 106kb cluster. (en)
- La naftomicina A è una molecola isolata sotto forma di pigmento giallo da Streptomyces collinus e mostra attività antibatteriche, antimicotiche e antitumorali. Le naftomicine rappresentano la famiglia di molecole con la catena di carbonio ansa-alifatica più lunga tra le ansamicine. Le origini biosintetiche dello scheletro carbonioso sono state studiate sfruttando l'enzima polichetide sintasi (PKS1) attraverso l'uso di precursori marcati con 13C e successiva analisi del prodotto tramite 13C-NMR. Al momento, ben trentadue geni per la biosintesi della naftomicina sono stati identificati all'interno di un cluster di 106 kb. Per confermare il suo coinvolgimento nella via biosintetica, è stato clonato e sequenziato attraverso la delezione di una regione di 7.2 kb. La via biosintetica proposta per la naftomicina. A, adenilazione; KS, chetosintasi; AT, aciltransferasi; T, proteina portatrice dell'acile o proteina portatrice del peptidile; DH, disidratasi; KR, chetoreduttasi; (*) dominio ridondante. (it)
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