About: NAD+ Five-prime cap

Facets (new session)
Description
Metadata
Settings
- Rule:
- Inverse Functional Properties:
- "Same As":

About: NAD+ Five-prime cap Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Thing, within Data Space : dbpedia.org associated with source document(s)
QRcode icon

http://dbpedia.org/describe/?url=http%3A%2F%2Fdbpedia.org%2Fresource%2FNAD%2B_Five-prime_cap

In molecular biology, the NAD+ five-prime cap (NAD+ 5’ cap) refers to a molecule of nicotinamide adenine dinucleotide (NAD+), a nucleoside-containing metabolite, covalently bonded the 5’ end of cellular mRNA. While the more common methylated guanosine (m7G) cap is added to RNA by a capping complex that associates with RNA polymerase II (RNAP II), the NAD cap is added during transcriptional initiation by the RNA polymerase itself, acting as a non-canonical initiating nucleotide (NCIN). As such, while m7G capping can only occur in organisms possessing specialized capping complexes, because NAD capping is performed by RNAP itself, it is hypothesized to occur in most, if not all, organisms.

Attributes	Values
rdfs:label	NAD+ Five-prime cap (en)
rdfs:comment	In molecular biology, the NAD+ five-prime cap (NAD+ 5’ cap) refers to a molecule of nicotinamide adenine dinucleotide (NAD+), a nucleoside-containing metabolite, covalently bonded the 5’ end of cellular mRNA. While the more common methylated guanosine (m7G) cap is added to RNA by a capping complex that associates with RNA polymerase II (RNAP II), the NAD cap is added during transcriptional initiation by the RNA polymerase itself, acting as a non-canonical initiating nucleotide (NCIN). As such, while m7G capping can only occur in organisms possessing specialized capping complexes, because NAD capping is performed by RNAP itself, it is hypothesized to occur in most, if not all, organisms. (en)
dcterms:subject	Cellular respiration Coenzymes Nucleotides Anti-aging substances
Wikipage page ID	63623716 (xsd:integer)
Wikipage revision ID	1107608006 (xsd:integer)
Link from a Wikipage to another Wikipage	Prokaryotes Proteins Messenger RNA Next-generation sequencing Prokaryote Human Decapping complex Nudix hydrolase MRNA Cellular respiration Coenzymes Enzyme Enzymes Glucose RNA polymerase II Arabidopsis thaliana Calorie restriction Post-translational modification Stationary phase (biology) Bacteria dbr:7-Methylguanosine Nucleotides Escherichia coli Eukaryote Eukaryotes Eukaryotic Nicotinamide adenine dinucleotide Glyceraldehyde 3-phosphate dehydrogenase RNA Receptor (biochemistry) Ribonucleoprotein Hydrolysis Anti-aging substances Translation (biology) Yeast RNA polymerase Five-prime cap Molecular biology Polyadenylation Ribonuclease E Protein ligands Cellular metabolism M7G Polyadenylated RNAP II 5' end
sameAs	NAD+ Five-prime cap NAD+ Five-prime cap
dbp:wikiPageUsesTemplate	dbt:Orphan dbt:Reflist
has abstract	In molecular biology, the NAD+ five-prime cap (NAD+ 5’ cap) refers to a molecule of nicotinamide adenine dinucleotide (NAD+), a nucleoside-containing metabolite, covalently bonded the 5’ end of cellular mRNA. While the more common methylated guanosine (m7G) cap is added to RNA by a capping complex that associates with RNA polymerase II (RNAP II), the NAD cap is added during transcriptional initiation by the RNA polymerase itself, acting as a non-canonical initiating nucleotide (NCIN). As such, while m7G capping can only occur in organisms possessing specialized capping complexes, because NAD capping is performed by RNAP itself, it is hypothesized to occur in most, if not all, organisms. The NAD+ 5’ cap has been observed in bacteria, contrary to the long-held belief that prokaryotes lacked 5’-capped RNA, as well as on the 5’ cap of eukaryotic mRNA, in place of the m7G cap. This modification also potentially allows for selective degradation of RNA within prokaryotes as different pathways are involved in the degradation of NAD+-capped and uncapped 5′-triphosphate-RNAs. In eukaryotic cells, while the more commonly observed m7G cap promotes the stability of the mRNA and supports translation, the NAD+ cap targets the RNA transcript for decay, facilitated by the non-canonical decapping enzyme, DXO. Considering the centrality of NAD in redox chemistry and post-translational protein modification, its attachment to RNA represents potentially undiscovered pathways in RNA metabolism and regulation. (en)
prov:wasDerivedFrom	wikipedia-en:NAD+_Five-prime_cap?oldid=1107608006&ns=0
page length (characters) of wiki page	11370 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:NAD+_Five-prime_cap
is foaf:primaryTopic of	wikipedia-en:NAD+_Five-prime_cap

Faceted Search & Find service v1.17_git139 as of Feb 29 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 08.03.3330 as of Mar 19 2024, on Linux (x86_64-generic-linux-glibc212), Single-Server Edition (62 GB total memory, 54 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software