Mpho Phalatse (born 7 November 1977) is a South African medical doctor and politician who is the Executive Mayor of the City of Johannesburg Metropolitan Municipality. A member of the Democratic Alliance, she was elected to the position on 22 November 2021 . She is the first woman to serve as mayor of the metropolitan municipality, which was established in 2000. She is the first black woman to serve as mayor of the city of Johannesburg and the second female mayor of the city after , who served from 1945 to 1946.