The Mississippi Valley League (MVL) was a baseball Class D level minor league that operated from 1922 through 1933. Playing its last year as a Class B level league, the league franchises were based in Iowa and Illinois. Like many leagues at the time, the Great Depression led to its demise. The Mississippi Valley League was founded by Michael H. Sexton, of Rock Island, Illinois, who was then president of the National Association of Professional Baseball Leagues.