About: Miguel Ondetti

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Miguel Angel Ondetti (May 14, 1930 – August 23, 2004) was an Argentine-born American chemist who first synthesized captopril, the first ACE inhibitor that was used to treat heart disease. With his co-worker, David Cushman, he won the 1999 Lasker Award for: "developing an innovative approach to drug design based on protein structure and using it to create the ACE inhibitors, powerful oral agents for the treatment of high blood pressure, heart failure, and diabetic kidney disease".

Attributes	Values
rdf:type	Thing foaf:Person person dul:NaturalPerson Eukaryote Person Human Animal yago:WikicatAmericanBiochemists yago:WikicatAmericanChemists yago:WikicatArgentineEmigrantsToTheUnitedStates yago:WikicatArgentineScientists animal eukaryote scientist species schema:Person yago:WikicatPeopleFromBuenosAires Scientist yago:Biochemist109854915 yago:CausalAgent100007347 yago:Chemist109913824 yago:Emigrant110051975 yago:LivingThing100004258 yago:Migrant110314952 yago:Object100002684 yago:Organism100004475 yago:Person100007846 yago:PhysicalEntity100001930 yago:WikicatHarvardMedicalSchoolPeople yago:YagoLegalActor yago:YagoLegalActorGeo yago:Scientist110560637 yago:Traveler109629752 yago:Whole100003553 umbel-rc:Scientist
rdfs:label	Miguel Ondetti (de) Miguel Ángel Ondetti (es) Miguel Ondetti (en) Miguel Ondetti (pl) Miguel Ondetti (pt)
rdfs:comment	Miguel Ángel Ondetti (14 de mayo de 1930 - 23 de agosto de 2004) fue un químico nacido en Argentina que sintetizó captopril, el primer inhibidor de la ECA que se utilizó para tratar enfermedades del corazón. Con su compañero de trabajo, , ganó el Premio Lasker de 1999 por: "desarrollar un enfoque innovador para el diseño de medicamentos basado en la estructura de la proteína y usarlo para crear los inhibidores de la ECA, potentes agentes orales para el tratamiento de la hipertensión, el corazón insuficiencia y enfermedad renal diabética ". (es) Miguel A. Ondetti (ur. 14 maja 1930 r. w Buenos Aires, zm. 23 sierpnia 2004 r.) - argentyńsko-amerykański naukowiec, pionier badań, które doprowadziły do odkrycia kaptoprylu, pierwszego doustnego inhibitora konwertazy angiotensyny stosowanego w terapii chorób układu sercowo-naczyniowego. (pl) Miguel Angel Ondetti (14 de maio de 1930 — 23 de agosto de 2004) foi um químico argentino naturalizado estadunidense. Foi o primeiro a sistetizar o captopril, o primeiro inibidor da enzima de conversão da angiotensina, usado no tratamento de doenças cardíacas. (pt) Miguel Angel Ondetti (* 23. Mai 1930 in Buenos Aires; † 23. August 2004) war ein argentinischer Chemiker. Er entwickelte mit David Cushman Captopril, den ersten ACE-Hemmer. Ondettis Eltern hatten italienische Vorfahren. Er besuchte eine Handelsschule und arbeitete als Buchhalter, bevor er sich für ein Studium entschloss. Da er keine höhere Schule besucht hatte, musste er anfangs im Selbststudium lernen, während er als Externer Prüfungen an der Universität absolvierte, bis er schließlich doch zum Studium der Chemie an der Universität von Buenos Aires zugelassen wurde. Nebenbei arbeitete er als Angestellter. Er erhielt den Lizenziats-Abschluss 1955 und wurde dort 1957 promoviert. Er forschte am Forschungsinstitut von Squibb in Argentinien, wobei er hauptsächlich unter Pflanzenalkaloiden nach (de) Miguel Angel Ondetti (May 14, 1930 – August 23, 2004) was an Argentine-born American chemist who first synthesized captopril, the first ACE inhibitor that was used to treat heart disease. With his co-worker, David Cushman, he won the 1999 Lasker Award for: "developing an innovative approach to drug design based on protein structure and using it to create the ACE inhibitors, powerful oral agents for the treatment of high blood pressure, heart failure, and diabetic kidney disease". (en)
foaf:name	Miguel Angel Ondetti (en)
name	Miguel Angel Ondetti (en)
birth place	Buenos Aires, Argentina
death date	2004-08-23 (xsd:date)
birth place	Buenos Aires, Argentina
birth date	1930-05-14 (xsd:date)
dcterms:subject	1930 births 2004 deaths People from Buenos Aires 20th-century American biochemists Recipients of the Lasker-DeBakey Clinical Medical Research Award Harvard Medical School people Argentine emigrants to the United States Argentine scientists
Wikipage page ID	3758526 (xsd:integer)
Wikipage revision ID	1115868239 (xsd:integer)
Link from a Wikipage to another Wikipage	dbr:Captopril Carbohydrate Princeton, New Jersey Science History Institute Alkaloid Perkin Medal University of Buenos Aires Electroplate Licentiate (degree) 1930 births Cholecystokinin Pharmaceutical industry Bristol-Myers Squibb Peptide synthesis 2004 deaths People from Buenos Aires ACE inhibitor American English 20th-century American biochemists Angiotensin Carboxypeptidase A Secretin Recipients of the Lasker-DeBakey Clinical Medical Research Award Harvard Medical School people Argentine emigrants to the United States Argentine scientists Lasker Award Sulfhydryl Copper sulfate PhD New Brunswick, New Jersey Science (journal) Chemical Heritage Foundation Buenos Aires, Argentina Bioassays dbr:Venancio_Deulofeu
Link from a Wikipage to an external page	https://web.archive.org/web/20070714100445/http:/www.invent.org/hall_of_fame/356.html https://oh.sciencehistory.org/oral-histories/ondetti-miguel-a%7Cwebsite=

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