Mexico competed at the 2022 World Athletics Championships in Eugene, United States, from 15 to 24 July 2022. The Federation of Mexican Athletics Associations entered 25 athletes. For the second time in a row, Mexico ended its participation in the World Athletics Championships without winning a medal. Mexico was ranked 67th place in the overall placing table with two points, thanks to Alegna González's seventh place in the women's 20 kilometres race walk.