In molecular biology, methylation induced premeiotically (MIP) is a process by which cytosines within repeated DNA sequences are de novo methylated prior to the sexual cycle. This process was first described in the ascomycete . MIP is dependent upon the gene masc1 which encodes a cytosine methyltransferase-like protein.At least one major function of the process appears to be genome defense. Related functions have been found in other fungi, including Neurospora and Aspergillus species.
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