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There are many methods to investigate protein–protein interactions which are the physical contacts of high specificity established between two or more protein molecules involving electrostatic forces and hydrophobic effects. Each of the approaches has its own strengths and weaknesses, especially with regard to the sensitivity and specificity of the method. A high sensitivity means that many of the interactions that occur are detected by the screen. A high specificity indicates that most of the interactions detected by the screen are occurring in reality.

Attributes	Values
rdf:type	software yago:WikicatBiochemistryMethods yago:WikicatMolecularBiologyTechniques yago:Ability105616246 yago:Abstraction100002137 yago:Appraisal105733583 yago:Assay105738625 yago:BasicCognitiveProcess105701944 yago:Classification105732756 yago:Cognition100023271 yago:Know-how105616786 yago:Method105660268 yago:Process105701363 yago:PsychologicalFeature100023100 yago:Technique105665146 yago:WikicatProteinMethods yago:WikicatProtein–proteinInteractionAssays
rdfs:label	Metody výzkumu protein-proteinových interakcí (cs) Méthodes d'investigation des interactions protéine–protéine (fr) Methods to investigate protein–protein interactions (en)
rdfs:comment	Il existe de nombreuses méthodes d'investigation des interactions protéine–protéine. Chaque méthode a ses avantages et ses inconvénients, en particulier pour ce qui concerne la sensibilité et la spécificité. Une haute sensibilité signifie que beaucoup des interactions qui existent seront détectées, alors qu'une haute spécificité veut dire que la plupart des interactions détectées existent vraiment. (fr) There are many methods to investigate protein–protein interactions which are the physical contacts of high specificity established between two or more protein molecules involving electrostatic forces and hydrophobic effects. Each of the approaches has its own strengths and weaknesses, especially with regard to the sensitivity and specificity of the method. A high sensitivity means that many of the interactions that occur are detected by the screen. A high specificity indicates that most of the interactions detected by the screen are occurring in reality. (en) Metody výzkumu protein-proteinových interakcí nám umožňují detekovat a hlouběji zkoumat interakce mezi rozmanitými proteiny. I přesto, že nukleotidová sekvence lidského genomu byla již zcela vyřešena, doposud nám nejsou známy funkce některých v ní zakódovaných proteinů. Funkci proteinu lze dobře zjistit, pokud se nám podaří odhalit jeho interakční partnery. Zároveň variabilita protein-proteinových interakcí, jejich regulace v čase a prostoru se podílejí na komplexitě celé řady dějů v organismech. K účelu výzkumu protein-proteinových interakcí byla (a stále je) vyvíjena celá paleta metod. Každá z nich má své výhody i nevýhody a je vhodná pro určitý typ proteinu. (cs)
dcterms:subject	Molecular biology techniques Protein methods Protein–protein interaction assays
Wikipage page ID	31045573 (xsd:integer)
Wikipage revision ID	1101141467 (xsd:integer)
Link from a Wikipage to another Wikipage	Epitope NMR Bissulfosuccinimidyl suberate Biacore Electrostatic force Mass spectrometry Saccharomyces cerevisiae RNA interference Protein–protein interaction CovalX Enzyme N-Hydroxysuccinimide Conformational change Cross-link Angstrom Antibody Leucine Ligand Single colour reflectometry Proximity ligation assay Macromolecular docking SPINE (molecular biology) Tandem affinity purification Microscale thermophoresis Bacteria Transcription (biology) Dissociation constant Job plot Lectin Molecular biology techniques Dynamic light scattering Flow-induced dispersion analysis Fluorescence anisotropy Fluorescence correlation spectroscopy Fluorescence cross-correlation spectroscopy Glycan Graph theory Isothermal titration calorimetry Dual polarisation interferometry Phage display Protein Rayleigh scattering Reporter gene Hydrophobic effect Water activity Protein methods Affinity electrophoresis Protein–protein interaction assays Bimolecular fluorescence complementation Binding constant Bio-layer interferometry Biological network Biological pathway Transformation (genetics) Diazirine Methionine Static light scattering Surface plasmon resonance Sensitivity and specificity Immunoelectrophoresis Immunoprecipitation dbr:DERB Photo-reactive amino acid analog MALDI Integrins Virial coefficient Bacterial two-hybrid screen Yeast two-hybrid ChIP Photoreactive amino acid SILAC Fluorescence resonance energy transfer

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