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About: Megaphone (molecule)     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:ChemicalSubstanceType, within Data Space : dbpedia.org associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceChemical compoundyago:WikicatMolecularFormulasyago:WikicatO-MethylatedNaturalPhenolsyago:Abstraction100002137yago:Agent114778436yago:Alcohol107884567yago:AliphaticCompound114601294yago:Alkene114713120yago:Beverage107881800yago:CausalAgent100007347yago:Chemical114806838yago:Communication100033020yago:Compound114818238yago:Drug103247620yago:DrugOfAbuse103248958yago:Element114840755yago:Fluid114939900yago:Food100021265yago:Formula106816935yago:Ketone114926294yago:Liquid114940386yago:Material114580897yago:Matter100020827yago:Message106598915yago:MolecularFormula106817173yago:OrganicCompound114727670yago:Part113809207yago:Phenol114989545yago:PhysicalEntity100001930yago:Quintessence114847103yago:Relation100031921yago:WikicatKetoneschemical compoundyago:Statement106722453yago:Substance100019613yago:Substance100020090yago:WikicatAlcoholsyago:WikicatAlkenesyago:WikicatEthersyago:WikicatPhenolEthersumbel-rc:ChemicalSubstanceType New Facet based on Instances of this Class

Megaphone is a cytotoxic neolignan obtained from Aniba megaphylla, a flowering plant of Laurel family which gave the compound its name. Megaphone has also been prepared synthetically. Studies carried out in the 1960s demonstrated that an alcoholic extract of the ground root of Aniba megaphylla inhibited, in vitro, growth of cells derived from human carcinoma of the nasopharynx. In 1978, the active components of the extract were isolated using silica gel chromatography, characterized and named as megaphone (C22H30O6, solid), megaphone acetate (C24H32O7, oily liquid) and megaphyllone acetate (C23H28O7, oily liquid). For comparison, megaphone acetate was also produced synthetically by reacting megaphone with acetic anhydride at 50 °C for 6 hours. Stirring an alcoholic solution of megaphone (m