The MasSpec Pen, or the precìso MasSpec Pen System, is a mass spectrometry (MS) based cancer detection and diagnosis system that can be used for ex vivo and in vivo tissue sample analysis. The system collects biological molecules from a tissue sample surface via a solid-liquid extraction mechanism and transports the molecules to a mass spectrometer for analysis. The composition of the extracted molecules can then be used to predict if the tissue sample analyzed contains cancerous cells using machine learning algorithms and statistical models. In early-stage clinical research, the MasSpec Pen system was able to distinguish various cancer tissues, including thyroid, breast, lung, and ovarian tumor tissues, from their normal counterparts with an overall accuracy of 96.3%. A follow-up study in
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| - The MasSpec Pen, or the precìso MasSpec Pen System, is a mass spectrometry (MS) based cancer detection and diagnosis system that can be used for ex vivo and in vivo tissue sample analysis. The system collects biological molecules from a tissue sample surface via a solid-liquid extraction mechanism and transports the molecules to a mass spectrometer for analysis. The composition of the extracted molecules can then be used to predict if the tissue sample analyzed contains cancerous cells using machine learning algorithms and statistical models. In early-stage clinical research, the MasSpec Pen system was able to distinguish various cancer tissues, including thyroid, breast, lung, and ovarian tumor tissues, from their normal counterparts with an overall accuracy of 96.3%. A follow-up study in (en)
- A MasSpec Pen, ou precìso MasSpec Pen System, é um sistema de detecção e diagnóstico de câncer baseado em espectrometria de massa (MS) que pode ser usado para análises de amostras de tecido ex vivo e in vivo O sistema coleta moléculas biológicas de uma superfície de amostra de tecido, por meio de um mecanismo de extração sólido-líquido e transporta as moléculas para um espectrômetro de massa para análise. A composição das moléculas extraídas pode então ser usada para prever se a amostra de tecido analisada contém células cancerosas usando algoritmos de aprendizado de máquina e Na pesquisa clínica em estágio inicial, o sistema MasSpec Pen foi capaz de distinguir vários tecidos cancerígenos, incluindo tecidos tumorais de tireóide, mama, pulmão e ovário, de seus equivalentes normais com uma (pt)
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| - The MasSpec Pen, or the precìso MasSpec Pen System, is a mass spectrometry (MS) based cancer detection and diagnosis system that can be used for ex vivo and in vivo tissue sample analysis. The system collects biological molecules from a tissue sample surface via a solid-liquid extraction mechanism and transports the molecules to a mass spectrometer for analysis. The composition of the extracted molecules can then be used to predict if the tissue sample analyzed contains cancerous cells using machine learning algorithms and statistical models. In early-stage clinical research, the MasSpec Pen system was able to distinguish various cancer tissues, including thyroid, breast, lung, and ovarian tumor tissues, from their normal counterparts with an overall accuracy of 96.3%. A follow-up study in illustrating the use of the device for detection of serous ovarian carcinoma in ex vivo tissue biopsies allowed for the discrimination of normal and cancerous ovarian samples with a clinical sensitivity and specificity of 94.0% and 94.4%, respectively. (en)
- A MasSpec Pen, ou precìso MasSpec Pen System, é um sistema de detecção e diagnóstico de câncer baseado em espectrometria de massa (MS) que pode ser usado para análises de amostras de tecido ex vivo e in vivo O sistema coleta moléculas biológicas de uma superfície de amostra de tecido, por meio de um mecanismo de extração sólido-líquido e transporta as moléculas para um espectrômetro de massa para análise. A composição das moléculas extraídas pode então ser usada para prever se a amostra de tecido analisada contém células cancerosas usando algoritmos de aprendizado de máquina e Na pesquisa clínica em estágio inicial, o sistema MasSpec Pen foi capaz de distinguir vários tecidos cancerígenos, incluindo tecidos tumorais de tireóide, mama, pulmão e ovário, de seus equivalentes normais com uma precisão geral de 96,3%. Um estudo de acompanhamento ilustrando o uso do dispositivo para detecção de carcinoma seroso de ovário em biópsias de tecido ex vivo permitiu a discriminação de amostras de ovário normais e cancerosas com uma sensibilidade clínica e especificidade de 94,0% e 94,4%, respectivamente. (pt)
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