Mary Lowe Scranton (April 27, 1918 – December 26, 2015) was an American consultant, community advocate and academic trustee. She served as the First Lady of Pennsylvania from 1963 to 1967 during the administration of her husband, William Scranton, the 38th Governor of Pennsylvania and 1964 U.S. presidential candidate. She focused on housing and community affairs issues in Northeastern Pennsylvania after her tenure as Pennsylvania's First Lady.