Mario Santillán Hernández (born April 22, 1981) is a Paralympic athlete from Mexico competing mainly in category T46 long-distance events. He is missing his right hand. He competed in the 2008 Summer Paralympics in Beijing, China. There he won a gold medal in the men's Marathon - T46 event in world record time. He also won a bronze medal in the men's 5000 metres - T46 event. As of January 2013, his T46 marathon world record, set in Beijing, remains unbeaten.