State Route 16 (SR 16) is a numbered state highway in Maine, United States. SR 16 runs from the New Hampshire state line (signed as NH-16) at Wentworth Location (near ) in the west to Orono at the eastern terminus. State Route 16 runs a total of 190 miles (310 km), passing mostly through rural areas, with the largest population center at its eastern terminus in Orono at Interstate 95 (I-95). Route 16 follows a rather circuitous route between the two states, originating in Portsmouth, New Hampshire, at Interstate 95, and re-intersecting Interstate 95 some 340 miles (550 km) later in Orono.