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MT-45 (IC-6) is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-45 has around 80% the potency of morphine, with almost all opioid activity residing in the (S) enantiomer (the opposite stereochemistry from the related drug lefetamine). It has been used as a lead compound from which a large family of potent opioid drugs have been developed, including full agonists, partial agonists, and antagonists at the three main opioid receptor subtypes.

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  • MT-45
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  • MT-45 (IC-6) is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-45 has around 80% the potency of morphine, with almost all opioid activity residing in the (S) enantiomer (the opposite stereochemistry from the related drug lefetamine). It has been used as a lead compound from which a large family of potent opioid drugs have been developed, including full agonists, partial agonists, and antagonists at the three main opioid receptor subtypes.
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ATC prefix
  • None
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CAS supplemental
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IUPAC name
legal DE
  • Anlage II
legal UK
  • Class A
legal US
  • Schedule I
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PubChem
routes of administration
SMILES
  • c3ccccc3CCNCCN1C4CCCCC4
StdInChI
StdInChIKey
  • IGBRRSIHEGCUEN-UHFFFAOYSA-N
synonyms
  • MT-45, IC-6
UNII
  • Q2640DPW33
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  • changed
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  • MT-45 (IC-6) is an opioid analgesic drug invented in the 1970s by Dainippon Pharmaceutical Co. It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-45 has around 80% the potency of morphine, with almost all opioid activity residing in the (S) enantiomer (the opposite stereochemistry from the related drug lefetamine). It has been used as a lead compound from which a large family of potent opioid drugs have been developed, including full agonists, partial agonists, and antagonists at the three main opioid receptor subtypes. Recreational use of MT-45 has been associated with hearing loss and unconsciousness. MT-45 became a class A drug in the UK on 11 March 2015 MT-45 is banned in the Czech Republic. The Canadian Controlled Drugs and Substances Act was amended in 2016 to include the substance as a Schedule I substance. Possession without legal authority can result in maximum 7 years imprisonment. Further, Health Canada amended the Food and Drug Regulations in May, 2016 to classify MT-45 as a restricted drug. Only those with a law enforcement agency, person with an exemption permit or institutions with Minister's authorization may possess the drug in Canada. In the United States the DEA placed MT-45 in Schedule 1 of the Controlled Substance Act. This took effect January 12, 2018.
CAS number
  • 52694-52-7 (S) enantiomer
  • 52694-55-0
FDA UNII code
  • Q2640DPW33
PubChem
  • 431865
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