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Myristoylated alanine-rich C-kinase substrate is a protein that in humans is encoded by the MARCKS gene.It plays important roles in cell shape, cell motility, secretion, transmembrane transport, regulation of the cell cycle, and neural development. Recently, MARCKS has been implicated in the exocytosis of a number of vesicles and granules such as mucin and chromaffin.It is also the name of a protein family, of which MARCKS is the most studied member. They are intrinsically disordered proteins, with an acidic pH, with high proportions of alanine, glycine, proline, and glutamic acid. They are membrane-bound through a lipid anchor at the N-terminus, and a polybasic domain in the middle. They are regulated by Ca2+/calmodulin and protein kinase C. In their unphosphorylated form, they bind to ac

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  • MARCKS (es)
  • MARCKS (en)
  • MARCKS (uk)
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  • Myristoylated alanine-rich C-kinase substrate is a protein that in humans is encoded by the MARCKS gene.It plays important roles in cell shape, cell motility, secretion, transmembrane transport, regulation of the cell cycle, and neural development. Recently, MARCKS has been implicated in the exocytosis of a number of vesicles and granules such as mucin and chromaffin.It is also the name of a protein family, of which MARCKS is the most studied member. They are intrinsically disordered proteins, with an acidic pH, with high proportions of alanine, glycine, proline, and glutamic acid. They are membrane-bound through a lipid anchor at the N-terminus, and a polybasic domain in the middle. They are regulated by Ca2+/calmodulin and protein kinase C. In their unphosphorylated form, they bind to ac (en)
  • El substrato de proteína quinasa C rico en alanina miristoilada (del inglés, myristoylated alanine-rich C-kinase substrate) es una proteína que en los humanos es codificada por el gen MARCKS.​​​ Juega un importante rol en la forma de la célula, la migración celular, secreción, transporte de transmembrana, regulación del ciclo celular, y desarrollo neural.​ Recientemente, el MARCKS ha sido implicada en la exocitosis de un número de vesículas y gránulos como la mucina y la cromafina. (es)
  • MARCKS (англ. Myristoylated alanine rich protein kinase C substrate) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми. Довжина поліпептидного ланцюга білка становить 332 амінокислот, а молекулярна маса — 31 555. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: Треонін V: Валін (uk)
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  • Myristoylated alanine-rich C-kinase substrate is a protein that in humans is encoded by the MARCKS gene.It plays important roles in cell shape, cell motility, secretion, transmembrane transport, regulation of the cell cycle, and neural development. Recently, MARCKS has been implicated in the exocytosis of a number of vesicles and granules such as mucin and chromaffin.It is also the name of a protein family, of which MARCKS is the most studied member. They are intrinsically disordered proteins, with an acidic pH, with high proportions of alanine, glycine, proline, and glutamic acid. They are membrane-bound through a lipid anchor at the N-terminus, and a polybasic domain in the middle. They are regulated by Ca2+/calmodulin and protein kinase C. In their unphosphorylated form, they bind to actin filaments, causing them to crosslink, and sequester acidic membrane phospholipids such as PIP2. The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. (en)
  • El substrato de proteína quinasa C rico en alanina miristoilada (del inglés, myristoylated alanine-rich C-kinase substrate) es una proteína que en los humanos es codificada por el gen MARCKS.​​​ Juega un importante rol en la forma de la célula, la migración celular, secreción, transporte de transmembrana, regulación del ciclo celular, y desarrollo neural.​ Recientemente, el MARCKS ha sido implicada en la exocitosis de un número de vesículas y gránulos como la mucina y la cromafina. Son proteínas ácidas con grandes proporciones de alanina, glicina, prolina y ácido glutámico. Son ligados por la membrana a través de un enlace de lípidos en el término N, y de dominio polivalente en el centro. Son reguladas por la Ca2+/calmodulina y la proteína quinasa C. En su forma sin fosforilar, se unen a los filamentos de actina, causando que se formen enlaces cruzados, y secuestran fosfolípidos de membrana ácida como el PIP2. La proteína codificada por este gen es un substrato de la proteína quinasa C. Se localiza en la membrana plasmática y es una proteína de enlaces cruzados con los filamentos de actina. La fosforilación por la proteína quinasa C o el enlace a calcio-calmodulina inhibe su asociación con la actina y con la membrana plasmática, llevando a su presencia en el citoplasma. Se cree que la proteína está implicada en la migración celular, la fagocitosis, el tráfico de membranas y la mitogénesis.​ (es)
  • MARCKS (англ. Myristoylated alanine rich protein kinase C substrate) – білок, який кодується однойменним геном, розташованим у людей на короткому плечі 6-ї хромосоми. Довжина поліпептидного ланцюга білка становить 332 амінокислот, а молекулярна маса — 31 555. Послідовність амінокислот A: АланінC: ЦистеїнD: Аспарагінова кислотаE: Глутамінова кислотаF: ФенілаланінG: ГліцинH: ГістидинK: ЛізинL: ЛейцинM: МетіонінN: АспарагінP: ПролінQ: ГлутамінR: АргінінS: СеринT: Треонін V: Валін Кодований геном білок за функцією належить до фосфопротеїнів. Білок має сайт для зв'язування з молекулою актину, молекулою кальмодуліну. Локалізований у цитоплазмі, цитоскелеті, мембрані. (uk)
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