About: Lysergic acid 2,4-dimethylazetidide     Goto   Sponge   NotDistinct   Permalink

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Lysergic acid 2,4-dimethylazetidide (LA-SS-Az, LSZ) is an analog of LSD developed by the team led by David E. Nichols at Purdue University. It was developed as a rigid analog of LSD with the diethylamide group constrained into an azetidine ring in order to map the binding site at the 5-HT2A receptor. There are three possible stereoisomers around the azetidine ring, with the (S,S)-(+) isomer being the most active, slightly more potent than LSD itself in drug discrimination tests using trained rats.

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  • Lysergic acid 2,4-dimethylazetidide
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  • Lysergic acid 2,4-dimethylazetidide (LA-SS-Az, LSZ) is an analog of LSD developed by the team led by David E. Nichols at Purdue University. It was developed as a rigid analog of LSD with the diethylamide group constrained into an azetidine ring in order to map the binding site at the 5-HT2A receptor. There are three possible stereoisomers around the azetidine ring, with the (S,S)-(+) isomer being the most active, slightly more potent than LSD itself in drug discrimination tests using trained rats.
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IUPAC name
  • [-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]-[-2,4-dimethylazetidin-1-yl]methanone
legal DE
  • NpSG
legal status
  • Illegal in Denmark, Sweden and Switzerland
legal UK
  • Class A
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routes of administration
  • Oral
SMILES
  • C[C@H]1C[C@@H]C
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  • DUKNIHFTDAXJON-CTQRGLTFSA-N
synonyms
  • Lysergic acid 2,4-dimethylazetidine, Diazedine, Lambda, LSZ
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index2 comment
  • -isomer, tartrate salt
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