Lowitja Lois O'Donoghue Smart, AC, CBE, DSG (born 1932) is an Aboriginal Australian retired public administrator. In 1990-1996 she was the inaugural chairperson of the Aboriginal and Torres Strait Islander Commission (ATSIC) (dismantled in 2004). She is patron of the Lowitja Institute, a research institute for Aboriginal & Torres Strait Islander health and wellbeing.