K. S. Chithra made her debut in the Tamil film industry through the song "Poojaikketha Poovithu" from the film Neethana Antha Kuyil (1985), which was composed by the Maestro Ilaiyaraaja. She was given the title Chinnakuyil after singing the song "Chinna Kuyil Paadum" from the 1985 released film Poove Poochudava. Director Fazil cast her for this song after Ilaiyaraaja got impressed with her song sung in original version in Malayalam for the film Nokkethadhoorathu Kannum Nattu in 1985 directed by himself.. For the folksy classical song "Paadariyaen Padippariyaen" from the film Sindhu Bhairavi (1986), she was awarded with the National Film Award for Best Female Playback Singer. Since then, she has recorded thousands of Tamil film songs composed by Ilaiyaraaja, A. R. Rahman, Deva, S. A. Rajkum