Limulus clotting factor overbar C (EC 3.4.21.84, factor C, limulus factor C) is an enzyme. This enzyme catalyses the following chemical reaction Selective cleavage of -Arg103-Ser- and -Ile124-Ile- bonds in limulus clotting factor B to form factor overbar B.Cleavage of -Pro-Arg- bonds in synthetic substrates
* EGF-like domain
* 3 Sushi domains
* one LCCL domain and one C-type lectin domain
* 2 more Sushi domains
* a trypsin domain This enzyme is useful in Limulus amebocyte lysate as the endotoxin-detecting element. It can be produced recombinantly.
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| - Limulus clotting factor C (en)
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| - Limulus clotting factor overbar C (EC 3.4.21.84, factor C, limulus factor C) is an enzyme. This enzyme catalyses the following chemical reaction Selective cleavage of -Arg103-Ser- and -Ile124-Ile- bonds in limulus clotting factor B to form factor overbar B.Cleavage of -Pro-Arg- bonds in synthetic substrates
* EGF-like domain
* 3 Sushi domains
* one LCCL domain and one C-type lectin domain
* 2 more Sushi domains
* a trypsin domain This enzyme is useful in Limulus amebocyte lysate as the endotoxin-detecting element. It can be produced recombinantly. (en)
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| - Limulus clotting factor overbar C (en)
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| - Limulus clotting factor overbar C (en)
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| - Tachypleus tridentatus (en)
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| - Limulus clotting factor overbar C (EC 3.4.21.84, factor C, limulus factor C) is an enzyme. This enzyme catalyses the following chemical reaction Selective cleavage of -Arg103-Ser- and -Ile124-Ile- bonds in limulus clotting factor B to form factor overbar B.Cleavage of -Pro-Arg- bonds in synthetic substrates This enzyme is isolated from the hemocyte granules of the horseshoe crabs Limulus and Tachypleus, where is serves as a LPS endotoxin-sensitive trypsin type serine protease to protect the organism from bacterial infection, initiating a cascade leading to coagulin formation. From the N-terminus to the C-terminus, the domains are:
* EGF-like domain
* 3 Sushi domains
* one LCCL domain and one C-type lectin domain
* 2 more Sushi domains
* a trypsin domain This enzyme is useful in Limulus amebocyte lysate as the endotoxin-detecting element. It can be produced recombinantly. (en)
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