A lupus erythematosus cell (LE cell), also known as Hargraves cell, is a neutrophil or macrophage that has phagocytized (engulfed) the denatured nuclear material of another cell. The denatured material is an absorbed hematoxylin body (also called an LE body). They are a characteristic of lupus erythematosus, but also found in similar connective tissue disorders or some autoimmune diseases like in severe rheumatoid arthritis. LE cells can be observed in drug-induced lupus, for example, following treatment with methyldopa.
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- LE cell (en)
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| - A lupus erythematosus cell (LE cell), also known as Hargraves cell, is a neutrophil or macrophage that has phagocytized (engulfed) the denatured nuclear material of another cell. The denatured material is an absorbed hematoxylin body (also called an LE body). They are a characteristic of lupus erythematosus, but also found in similar connective tissue disorders or some autoimmune diseases like in severe rheumatoid arthritis. LE cells can be observed in drug-induced lupus, for example, following treatment with methyldopa. (en)
- Se denomina célula LE (también, célula del lupus) a una célula fagocítica del sistema inmune que ha fagocitado el material nuclear desnaturalizado de algún otro tipo de célula. Por lo general, se trata de un macrófago o un neutrófilo. El núcleo desnaturalizado puede ser observado ocupando la porción central de la célula fagocítica (esto es conocido como cuerpo LE), mientras que el propio núcleo de la célula fagocítica por lo general queda extendido en forma de herradura en la periferia. Las células LE fueron descubiertas en 1948 por Hargraves y colaboradores. (es)
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| - Se denomina célula LE (también, célula del lupus) a una célula fagocítica del sistema inmune que ha fagocitado el material nuclear desnaturalizado de algún otro tipo de célula. Por lo general, se trata de un macrófago o un neutrófilo. El núcleo desnaturalizado puede ser observado ocupando la porción central de la célula fagocítica (esto es conocido como cuerpo LE), mientras que el propio núcleo de la célula fagocítica por lo general queda extendido en forma de herradura en la periferia. El observar este tipo de células en un extendido de médula ósea o incluso a veces en uno de sangre periférica es característico del lupus eritematoso sistémico, aunque no patognomónico del mismo, pues también pueden ser observadas en otras patologías autoinmunes del tejido conectivo. Las células LE fueron descubiertas en 1948 por Hargraves y colaboradores. (es)
- A lupus erythematosus cell (LE cell), also known as Hargraves cell, is a neutrophil or macrophage that has phagocytized (engulfed) the denatured nuclear material of another cell. The denatured material is an absorbed hematoxylin body (also called an LE body). They are a characteristic of lupus erythematosus, but also found in similar connective tissue disorders or some autoimmune diseases like in severe rheumatoid arthritis. LE cells can be observed in drug-induced lupus, for example, following treatment with methyldopa. The LE cell was discovered in bone marrow in 1948 by Malcolm McCallum Hargraves (1903–1982), a Physician and Practicing Histologist at the Mayo Clinic. Hargraves may have gained priority by suppressing a publication draft of John R. Haserick, who credits Dr. Dorothy Sundberg, chief hematologist at the University of Minnesota Hospitals, with first identifying LE cells. Classically, the LE cell is analyzed microscopically, but it is also possible to investigate this phenomenon by flow cytometry. LE cells shouldn't be confused with which have engulfed nuclear material, but with a visible chromatin rather than homogeneous appearance. (en)
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