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About: KNDy neuron     Goto   Sponge   NotDistinct   Permalink

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Kisspeptin, neurokinin B, and dynorphin (KNDy) neurons are neurons in the hypothalamus of the brain that are central to the hormonal control of reproduction. KNDy neurons in the hypothalamus coexpress kisspeptin, neurokinin B (NKB) and dynorphin. They are involved in the negative feedback of gonadotropin-releasing hormone (GnRH) release in the hypothalamic–pituitary–gonadal (HPG) axis. Sex steroids released from the gonads act on KNDy neurons as inhibitors of kisspeptin release. This inhibition provides negative feedback control on the HPG axis.