The Johns Hopkins–Syracuse lacrosse rivalry is an intercollegiate lacrosse rivalry between the Johns Hopkins Blue Jays and Syracuse Orange. The two programs are the most historically successful and winningest in collegiate lacrosse, combining for 60 national titles spanning the pre-NCAA and NCAA eras. Since the advent of the NCAA Division I Men's Lacrosse Championship, the Syracuse and Johns Hopkins have the first- and second-most titles respectively. Hopkins leads the series 30–28–1 through 2020.