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Intracellular pH (pHi) is the measure of the acidity or basicity (i.e., pH) of intracellular fluid. The pHi plays a critical role in membrane transport and other intracellular processes. In an environment with the improper pHi, biological cells may have compromised function. Therefore, pHi is closely regulated in order to ensure proper cellular function, controlled cell growth, and normal cellular processes. The mechanisms that regulate pHi are usually considered to be plasma membrane transporters of which two main types exist — those that are dependent and those that are independent of the concentration of bicarbonate (HCO−3). Physiologically normal intracellular pH is most commonly between 7.0 and 7.4, though there is variability between tissues (e.g., mammalian skeletal muscle tends to

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  • أس هيدروجيني داخل الخلية (ar)
  • PH intracel·lular (ca)
  • Intracellular pH (en)
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  • الأس الهيدروجيني داخل الخلية (بالإنجليزية: Intracellular pH)‏ ويُدعى اختصارًا pHi، هو الأس الهيدروجيني للسائل داخل الخلية، ويلعب دورًا مهمًا في عمليات النقل، ويُنظم هذا الأس بواسطة ناقلات الغشاء الخلوي، والتي تتواجد بنوعين رئيسيين، نوع مُستقل لا يحتاج بيكربونات، ونوع يعتمد على البيكربونات. معدل الأس الهيدروجيني داخل الخلية الطبيعي هو 7.4±0.1. (ar)
  • El pH intracel·lular (pHi) és el valor de pH quan es coneix el seu valor en el fluid intracel·lular. El pHi té un paper crític en el funcionament de la cèl·lula i se'n requereix una regulació estreta en les cèl·lules per a la supervivència. El pH intracel·lular es troba al voltant de 7,0 degut a la producció d'àcids. Conté baix nivell de HCO3- i per tant un pCO2 per sobre de 45 mmHg de pH no pot ser 7,4 però un pH més baix de 7,3 en les cèl·lules HEK293. (ca)
  • Intracellular pH (pHi) is the measure of the acidity or basicity (i.e., pH) of intracellular fluid. The pHi plays a critical role in membrane transport and other intracellular processes. In an environment with the improper pHi, biological cells may have compromised function. Therefore, pHi is closely regulated in order to ensure proper cellular function, controlled cell growth, and normal cellular processes. The mechanisms that regulate pHi are usually considered to be plasma membrane transporters of which two main types exist — those that are dependent and those that are independent of the concentration of bicarbonate (HCO−3). Physiologically normal intracellular pH is most commonly between 7.0 and 7.4, though there is variability between tissues (e.g., mammalian skeletal muscle tends to (en)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/Membrane_pH_gradient.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/Mitochondria_Intermembrane_pH.jpg
  • http://commons.wikimedia.org/wiki/Special:FilePath/PH_of_organelles.jpg
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  • El pH intracel·lular (pHi) és el valor de pH quan es coneix el seu valor en el fluid intracel·lular. El pHi té un paper crític en el funcionament de la cèl·lula i se'n requereix una regulació estreta en les cèl·lules per a la supervivència. Hi ha nombrosos mecanismes que fan canviar el pHi incloent la producció d'àcid metabòlic i el pas d'acids a través de la membrana del plasma, les membranes dels orgànuls i el procés de transport de membrana. Els mecanismes que regulen el pHi es consideren normalment transportadors de la membrana plasmàtica i n'hi ha dos tipus: els que són independents del HCO₃– i els que requerixen HCO₃–. El pH extracel·lular normal és 7,4 +/- .1.{http://www.uptodate.com/contents/chapter-10c-intracellular-ph} El pH intracel·lular es troba al voltant de 7,0 degut a la producció d'àcids. Conté baix nivell de HCO3- i per tant un pCO2 per sobre de 45 mmHg de pH no pot ser 7,4 però un pH més baix de 7,3 en les cèl·lules HEK293. (ca)
  • الأس الهيدروجيني داخل الخلية (بالإنجليزية: Intracellular pH)‏ ويُدعى اختصارًا pHi، هو الأس الهيدروجيني للسائل داخل الخلية، ويلعب دورًا مهمًا في عمليات النقل، ويُنظم هذا الأس بواسطة ناقلات الغشاء الخلوي، والتي تتواجد بنوعين رئيسيين، نوع مُستقل لا يحتاج بيكربونات، ونوع يعتمد على البيكربونات. معدل الأس الهيدروجيني داخل الخلية الطبيعي هو 7.4±0.1. (ar)
  • Intracellular pH (pHi) is the measure of the acidity or basicity (i.e., pH) of intracellular fluid. The pHi plays a critical role in membrane transport and other intracellular processes. In an environment with the improper pHi, biological cells may have compromised function. Therefore, pHi is closely regulated in order to ensure proper cellular function, controlled cell growth, and normal cellular processes. The mechanisms that regulate pHi are usually considered to be plasma membrane transporters of which two main types exist — those that are dependent and those that are independent of the concentration of bicarbonate (HCO−3). Physiologically normal intracellular pH is most commonly between 7.0 and 7.4, though there is variability between tissues (e.g., mammalian skeletal muscle tends to have a pHi of 6.8–7.1). There is also pH variation across different organelles, which can span from around 4.5 to 8.0. pHi can be measured in a number of different ways. (en)
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