Hygiene is an unincorporated community with a U.S. Post Office in Boulder County, Colorado, United States. Application for the first Hygiene Post Office was made by Jacob Stoner Flory of the United Church of the Brethren on May 28, 1883. Originally named Pella, the community's present name stems from a time when it had a sanatorium to work with tuberculosis patients. St. Vrain Church of the Brethren, a historic Church of the Brethren congregation, is located in the town.