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Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (converted to alcohols). It is a deeply colored solid that is usually encountered as a solution. Its chemical structure was determined in 1900. It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy.

AttributesValues
rdf:type
rdfs:label
  • Hämatoporphyrin (de)
  • Hematoporphyrin (en)
  • Гематопорфирин (ru)
  • 血紫質 (zh)
rdfs:comment
  • Hämatoporphyrin, auch Haematoporphyrin, (engl.: Hematoporphyrin) entsteht bei der sauren Hydrolyse des Hämoglobins. Hierbei werden die Proteinketten abgespalten sowie das Eisen(II)-ion entfernt. Außerdem werden die beiden Vinylgruppen hydratisiert, Hämatoporphyrin ist somit ein eisenfreies Häm. (de)
  • 血紫質（Hematoporphyrin）又稱血卟啉，是由血红蛋白酸水解後產生的内源卟啉。Nencki及Zaleski在1900年確定其化學結構。 自1920年代起，血紫質就已用作抗精神病药及抗抑郁药。 (zh)
  • Гематопорфирин (от гемато… и греч. porphyra — пурпур, багряный, цвет) — пигмент пурпурного цвета; образуется при действии на , гемин и гемоглобин сильных кислот. В незначительных количествах встречается в моче здорового человека; в больших количествах выделяется при отравлении свинцом, оксидом цинка, анемиях и болезнях печени. Впервые его структуру расшифровали еврейские учёные и в 1900 году. Гематопорфирин используется в качестве антидепрессанта и антипсихотического препарата начиная с 1920 года. (ru)
  • Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (converted to alcohols). It is a deeply colored solid that is usually encountered as a solution. Its chemical structure was determined in 1900. It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy. (en)
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  • http://commons.wikimedia.org/wiki/Special:FilePath/Hematoporphyrin.png
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ATC prefix
  • none (en)
c
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H
IUPAC name
legal status
  • Rx-only (en)
melting point
n
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PubChem
routes of administration
  • Oral (en)
SMILES
  • CC1=CCO (en)
StdInChI
StdInChIKey
  • KFKRXESVMDBTNQ-AMPAVEGJSA-N (en)
UNII
  • HBT6M5H379 (en)
verifiedrevid
has abstract
  • Hämatoporphyrin, auch Haematoporphyrin, (engl.: Hematoporphyrin) entsteht bei der sauren Hydrolyse des Hämoglobins. Hierbei werden die Proteinketten abgespalten sowie das Eisen(II)-ion entfernt. Außerdem werden die beiden Vinylgruppen hydratisiert, Hämatoporphyrin ist somit ein eisenfreies Häm. (de)
  • Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (converted to alcohols). It is a deeply colored solid that is usually encountered as a solution. Its chemical structure was determined in 1900. It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy. Hematoporphyrin has also been used as an antidepressant and antipsychotic since the 1920s. (en)
  • 血紫質（Hematoporphyrin）又稱血卟啉，是由血红蛋白酸水解後產生的内源卟啉。Nencki及Zaleski在1900年確定其化學結構。 自1920年代起，血紫質就已用作抗精神病药及抗抑郁药。 (zh)
  • Гематопорфирин (от гемато… и греч. porphyra — пурпур, багряный, цвет) — пигмент пурпурного цвета; образуется при действии на , гемин и гемоглобин сильных кислот. В незначительных количествах встречается в моче здорового человека; в больших количествах выделяется при отравлении свинцом, оксидом цинка, анемиях и болезнях печени. Впервые его структуру расшифровали еврейские учёные и в 1900 году. Гематопорфирин используется в качестве антидепрессанта и антипсихотического препарата начиная с 1920 года. (ru)
gold:hypernym
prov:wasDerivedFrom
page length (characters) of wiki page
CAS number
  • 14459-29-1
ChEMBL
  • 317840
FDA UNII code
  • HBT6M5H379
PubChem
  • 11103
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