About: Haybittle–Peto boundary

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The Haybittle–Peto boundary is a rule for deciding when to stop a clinical trial prematurely. It is named for John Haybittle and Richard Peto. The typical clinical trial compares two groups of patients. One group are given a placebo or conventional treatment, while the other group of patients are given the treatment that is being tested. The investigators running the clinical trial will wish to stop the trial early for ethical reasons if the treatment group clearly shows evidence of benefit. In other words, "when early results proved so promising it was no longer fair to keep patients on the older drugs for comparison, without giving them the opportunity to change."

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rdf:type	yago:WikicatSequentialExperiments yago:Abstraction100002137 yago:Act100030358 yago:Activity100407535 yago:Event100029378 yago:Experiment100639556 yago:Investigation100633864 yago:PsychologicalFeature100023100 yago:Research100636921 yago:Work100575741 yago:YagoPermanentlyLocatedEntity country yago:ScientificResearch100641820
rdfs:label	Haybittle–Peto boundary (en)
rdfs:comment	The Haybittle–Peto boundary is a rule for deciding when to stop a clinical trial prematurely. It is named for John Haybittle and Richard Peto. The typical clinical trial compares two groups of patients. One group are given a placebo or conventional treatment, while the other group of patients are given the treatment that is being tested. The investigators running the clinical trial will wish to stop the trial early for ethical reasons if the treatment group clearly shows evidence of benefit. In other words, "when early results proved so promising it was no longer fair to keep patients on the older drugs for comparison, without giving them the opportunity to change." (en)
dcterms:subject	Sequential experiments Clinical research
Wikipage page ID	27629910 (xsd:integer)
Wikipage revision ID	1017187944 (xsd:integer)
Link from a Wikipage to another Wikipage	Sequential experiments Richard Peto Clinical trial Clinical research John Haybittle Placebo Pocock boundary Stopping rule dbr:O'Brien–Fleming_boundary
sameAs	Haybittle–Peto boundary Haybittle–Peto boundary Haybittle–Peto boundary
dbp:wikiPageUsesTemplate	dbt:Reflist dbt:Use_dmy_dates
has abstract	The Haybittle–Peto boundary is a rule for deciding when to stop a clinical trial prematurely. It is named for John Haybittle and Richard Peto. The typical clinical trial compares two groups of patients. One group are given a placebo or conventional treatment, while the other group of patients are given the treatment that is being tested. The investigators running the clinical trial will wish to stop the trial early for ethical reasons if the treatment group clearly shows evidence of benefit. In other words, "when early results proved so promising it was no longer fair to keep patients on the older drugs for comparison, without giving them the opportunity to change." The Haybittle–Peto boundary is one such stopping rule, and it states that if an interim analysis shows a probability of equal to, or less than 0.001 that a difference as extreme or more between the treatments is found, given that the null hypothesis is true, then the trial should be stopped early. The final analysis is still evaluated at the normal level of significance (usually 0.05). The main advantage of the Haybittle–Peto boundary is that the same threshold is used at every interim analysis, unlike the , which changes at every analysis. Also, using the Haybittle–Peto boundary means that the final analysis is performed using a 0.05 level of significance as normal, which makes it easier for investigators and readers to understand. The main argument against the Haybittle–Peto boundary is that some investigators believe that the Haybittle–Peto boundary is too conservative and makes it too difficult to stop a trial. (en)
gold:hypernym	Rule
prov:wasDerivedFrom	wikipedia-en:Haybittle–Peto_boundary?oldid=1017187944&ns=0
page length (characters) of wiki page	4074 (xsd:nonNegativeInteger)
foaf:isPrimaryTopicOf	wikipedia-en:Haybittle–Peto_boundary
is Link from a Wikipage to another Wikipage of	Reigate Grammar School Haybittle-Peto boundary John Haybittle List of statistics articles Pocock boundary Sequential analysis
is Wikipage redirect of	Haybittle-Peto boundary
is foaf:primaryTopic of	wikipedia-en:Haybittle–Peto_boundary

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