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About: HTR3A     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:Transmission106251781, within Data Space : dbpedia.org associated with source document(s)

Type: ThingBiomoleculegeneBiomoleculeGeneyago:WikicatNeurotransmittersyago:Abstraction100002137yago:Act100030358yago:Channel106259898yago:Chemical114806838yago:Communication106252138yago:Compound114818238yago:Event100029378yago:Material114580897yago:Matter100020827yago:Neurochemical114807410yago:Neurotransmitter114807558yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:PsychologicalFeature100023100yago:Relation100031921yago:WikicatIonChannelsyago:YagoPermanentlyLocatedEntityHumanGeneproteinyago:Substance100019613yago:Transmission106251781 New Facet based on Instances of this Class

5-hydroxytryptamine receptor 3A is a protein that in humans is encoded by the HTR3A gene. The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. The A subunit is the only one that can be expressed alone and forms homomers with a very low single channel conductance of 0.6pS. When combined with the B subunit and expressed as a heteromer, the single channel conductance increases immensely. Alternatively spliced transcript variants encoding different isoforms have been identified.