About: HLA-B27

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Human leukocyte antigen (HLA) B27 (subtypes B*2701-2759) is a class I surface antigen encoded by the B locus in the major histocompatibility complex (MHC) on chromosome 6 and presents antigenic peptides (derived from self and non-self antigens) to T cells. HLA-B27 is strongly associated with ankylosing spondylitis and other associated inflammatory diseases, such as psoriatic arthritis, inflammatory bowel disease, and reactive arthritis.

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rdf:type	Thing yago:Abstraction100002137 yago:Allele105437785 yago:Arrangement107938773 yago:Attribute100024264 yago:Chemical114806838 yago:Compound114818238 yago:Condition113920835 yago:Disorder114052403 yago:Gene105436752 yago:Group100031264 yago:Macromolecule114944888 yago:Material114580897 yago:Matter100020827 yago:Molecule114682133 yago:Ordering108456993 yago:OrganicCompound114727670 yago:Part113809207 yago:PhysicalCondition114034177 yago:PhysicalEntity100001930 yago:Protein114728724 yago:Relation100031921 yago:WikicatHLA-BAlleles yago:WikicatImmuneSystemDisorders yago:Sequence108459252 yago:Series108457976 yago:State100024720 yago:Substance100019613 yago:Thing100002452 yago:Unit109465459
rdfs:label	HLA-B27 (ar) HLA-B27 (ca) HLA-B27 (de) HLA-B27 (es) HLA-B27 (fr) HLA-B27 (en)
rdfs:comment	HLA-B27 هو نمط مصلي من مستضد الكريات البيضاء البشرية-ب. (ar) HLA-B27 ist eine Variante des humanen Proteinkomplexes Human Leukocyte Antigen-B (HLA-B). HLA-B gehört zur Gruppe der MHC-Klasse-I-Proteinkomplexe, die sich auf der Oberfläche nahezu aller Zellen des Organismus befinden und wichtige Funktionen des Immunsystems regulieren. MHC-Komplexe präsentieren kurze Proteinabschnitte (Antigene) an der Zelloberfläche, wo sie von T-Lymphozyten gebunden werden können. Mutationen im HLA-B-Gen werden mit bestimmten Autoimmunerkrankungen (Spondyloarthritiden) in Verbindung gebracht. (de) Human leukocyte antigen (HLA) B27 (subtypes B2701-2759) is a class I surface antigen encoded by the B locus in the major histocompatibility complex (MHC) on chromosome 6 and presents antigenic peptides (derived from self and non-self antigens) to T cells. HLA-B27 is strongly associated with ankylosing spondylitis and other associated inflammatory diseases, such as psoriatic arthritis, inflammatory bowel disease, and reactive arthritis. (en) L'antigène HLA-B27 (human leucocyte antigen B27) est un antigène de surface de classe I, codé par le locus B du complexe majeur d'histocompatibilité, sur le chromosome 6. Sa fréquence dans la population générale varie de 8 % chez les Européens à 0,5 à 1 % chez les Japonais. Sa présence est associée à un certain nombre de maladies auto-immunes, comme la spondylarthrite ankylosante, ce qui signifie qu'un individu porteur du HLA-B27 a significativement plus de risque de développer ces maladies qu'un autre individu. (fr) L'antigen leucocitari humà B27 o HLA-B27 (subtipus B2701-2724) és un antigen de superfície classe I codificat pel locus B en el complex d'histocompatibilitat principal en el cromosoma 6 i es presenta a les cèl·lules T. L'HLA-B27 està fortament associat amb un cert conjunt de malalties autoimmunitàries, es poden recordar amb el PAIR mnemònic i inclouen psoriasi, espondilitis anquilosant, malaltia inflamatòria intestinal i artritis reactiva. (ca) El antígeno leucocitario humano B27 (subtipos B27:01-27:135) es un antígeno de superficie de clase I codificado en el locus B del Complejo principal de histocompatibilidad (MHC) humano en el brazo corto del cromosoma 6 y presenta péptidos endógenos procedentes de la degradación de proteínas en el núcleo o citosol de la célula a los linfocitos T citotóxicos (CD8+). HLA-B27 está fuertemente asociado con una serie de enfermedades autoinmunitarias conocidas genéricamente como .“ (es)
foaf:depiction
dcterms:subject	HLA-B alleles Medical mnemonics Immune system disorders
Wikipage page ID	539882 (xsd:integer)
Wikipage revision ID	1099851564 (xsd:integer)
Link from a Wikipage to another Wikipage	Scandinavia Endoplasmic reticulum Ankylosing spondylitis Antigen dbr:Beta-2_microglobulin Peptide Cytotoxic T cell Ulcerative colitis Uveitis HLA-B alleles Psoriatic arthritis Major histocompatibility complex Pathology Autism Caucasian race HLA-B HLA-B57 Long-term nonprogressor European Bioinformatics Institute Chromosome 6 Fuchs' dystrophy Fuchs' dystrophy Han Chinese Medical mnemonics Immune system disorders Human leukocyte antigen Inflammatory bowel disease Yamato people Unfolded protein response T cell Seronegative spondyloarthropathy North African Lapland (region) Crohn's Iritis
Link from a Wikipage to an external page	http://www.BASDAI.com http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi%3FB2701 http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi%3FB2702 http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi%3FB2703 http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi%3FB2704 http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi%3FB2705 http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi%3FB2706 http://www.ebi.ac.uk/cgi-bin/imgt/hla/get_allele.cgi%3FB*2709 https://www.ncbi.nlm.nih.gov/pubmed/%3Fterm=hla+b27 https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P03989
sameAs	HLA-B27 HLA-B27 HLA-B27 HLA-B27 HLA-B27 HLA-B27

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