Henry Lee Prather (October 10, 1886 – September 23, 1964) was an American football and basketball coach. He served as the head football coach at the Southwestern Louisiana Industrial Institute for one season in 1912, compiling a record of 3–4. He is best known, however, for his tenures as the head football and men's basketball coach at Northwestern State University in Natchitoches, Louisiana. Northwestern State's basketball arena, Prather Coliseum, is named in his honor.