State Route 112 (SR 112) is a 189.84-mile-long (305.52 km) state highway that travels in a generally southwest-to-northeast orientation in the southwestern and central parts of the U.S. state of Georgia. It passes through portions of Grady, Mitchell, Worth, Turner, Wilcox, Pulaski, Bleckley, Twiggs, Wilkinson, and Baldwin counties, and connects the Cairo and Milledgeville areas of the state.