About: Genome-wide complex trait analysis

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Genome-wide complex trait analysis (GCTA) Genome-based restricted maximum likelihood (GREML) is a statistical method for variance component estimation in genetics which quantifies the total narrow-sense (additive) contribution to a trait's heritability of a particular subset of genetic variants (typically limited to SNPs with MAF >1%, hence terms such as "chip heritability"/"SNP heritability"). This is done by directly quantifying the chance genetic similarity of unrelated individuals and comparing it to their measured similarity on a trait; if two unrelated individuals are relatively similar genetically and also have similar trait measurements, then the measured genetics are likely to causally influence that trait, and the correlation can to some degree tell how much. This can be illustra

Attributes	Values
rdf:type	Thing software schema:CreativeWork work wikidata:Q386724 Software
rdfs:label	Genome-wide complex trait analysis (en)
rdfs:comment	Genome-wide complex trait analysis (GCTA) Genome-based restricted maximum likelihood (GREML) is a statistical method for variance component estimation in genetics which quantifies the total narrow-sense (additive) contribution to a trait's heritability of a particular subset of genetic variants (typically limited to SNPs with MAF >1%, hence terms such as "chip heritability"/"SNP heritability"). This is done by directly quantifying the chance genetic similarity of unrelated individuals and comparing it to their measured similarity on a trait; if two unrelated individuals are relatively similar genetically and also have similar trait measurements, then the measured genetics are likely to causally influence that trait, and the correlation can to some degree tell how much. This can be illustra (en)
foaf:name	GCTA (en)
foaf:homepage	https://cnsgenomics.com/software/gcta/
name	GCTA (en)
dcterms:subject	Medical genetics Molecular genetics Single-nucleotide polymorphisms Statistical genetics Behavioural genetics Quantitative genetics Twin studies Genetics studies
Wikipage page ID	50613151 (xsd:integer)
Wikipage revision ID	1109625729 (xsd:integer)
Link from a Wikipage to another Wikipage	Ronald Fisher Epistasis Method of moments (statistics) Meta-analysis Copy-number variations Animal breeding Best linear unbiased prediction Ridge regression Variance Design of experiments Medical genetics Molecular genetics Single-nucleotide polymorphisms Analysis of variance Genetic correlation Genome-wide association study Negative selection (natural selection) GNU General Public License Genealogy Mutations Debian-Installer MacOS Feature selection Identity by descent Autosomal Broad Institute Statistical genetics Jian Yang (geneticist) Linkage disequilibrium Linkage disequilibrium score regression Principal component analysis Statistical power Haplotype Behavioural genetics Quantitative genetics Twin studies Genetics studies Heritability Heritability of IQ Missing heritability problem Illumina (company) Dominance (genetics) Assortative mating Population stratification Frequency-dependent selection Measurement error Test-retest reliability Microsoft Windows X86 64 MIT License Mendelian randomization Minor allele frequency Single-nucleotide polymorphism Standard error External validity Imputation (genetics) Pleiotropy The Correlation between Relatives on the Supposition of Mendelian Inheritance Restricted maximum likelihood Twin study Polygenic Structural variation PLINK Sex-linked Ascertainment bias Dizygotic Inbreeding coefficient Mixed linear model Mutation load Lasso regression 1000 Genomes Spearman's correction for measurement error Monozygotic X-chromosome
Link from a Wikipage to an external page	http://ldsc.broadinstitute.org/about/ http://www.genetics.forestry.ubc.ca/ritland/reprints/1996_Evolution_HeritInFieldModel.pdf https://cnsgenomics.com/software/gcta/ https://cnsgenomics.shinyapps.io/gctaPower/ https://data.broadinstitute.org/alkesgroup/BOLT-LMM/

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