Francis Wayles Eppes (September 20, 1801 – May 30, 1881) was a planter and slave owner from Virginia who became a cotton planter in the Florida Territory and later civic leader in Tallahassee and surrounding Leon County, Florida. After reaching legal age and marrying, Eppes operated the Poplar Forest plantation which his grandfather President Thomas Jefferson had established in Bedford County, Virginia, which he inherited. However, in 1829 he moved with his family to near Tallahassee, Florida. Long interested in education, in 1856 Eppes donated land and money to designate a school in Tallahassee as one of the first two state-supported seminaries, now known as Florida State University. He served as president of its board of trustees for eight years.