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About: Fotemustine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.org associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceDrugyago:WikicatUreasyago:WikicatNitrosoCompoundsyago:Abstraction100002137yago:Chemical114806838yago:Cognition100023271yago:Compound105870180yago:Compound114818238yago:Concept105835747yago:Content105809192yago:Ester114850483yago:Idea105833840yago:Material114580897yago:Matter100020827yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:PsychologicalFeature100023100yago:Relation100031921drugyago:Substance100019613yago:Urea115085472yago:Whole105869584yago:WikicatPhosphonateEstersumbel-rc:DrugProduct New Facet based on Instances of this Class

Fotemustine is a nitrosourea alkylating agent used in the treatment of metastatic melanoma. It is available in Europe but has not been approved by the United States FDA. A study has shown that fotemustine produces improved response rates and but does not increase survival (over dacarbazine in the treatment of disseminated cutaneous melanoma. Median survival was 7.3 months with fotemustine versus 5.6 months with DTIC (P=.067). There was also toxicity prevalence in fotemustine arm. The main toxicity was grade 3 to 4 neutropenia (51% with fotemustine v 5% with DTIC) and thrombocytopenia (43% v 6%, respectively).