About: Fluotracen

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http://dbpedia.org/describe/?url=http%3A%2F%2Fdbpedia.org%2Fresource%2FFluotracen

Fluotracen (SKF-28,175) is a tricyclic drug which possesses dual antidepressant and antipsychotic activity. This profile of effects is similar to that of related agents like amoxapine, loxapine, and trimipramine which may also be used in the treatment of both depression and psychosis. It was believed that such duality would be advantageous in the treatment of schizophrenia, as depression is often comorbid with the disorder and usual antipsychotics often worsen such symptoms. In any case, however, fluotracen was never marketed.

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug yago:WikicatAntipsychotics yago:WikicatTricyclicAntidepressants yago:Agent114778436 yago:Antidepressant102718811 yago:CausalAgent100007347 yago:Drug103247620 yago:DrugOfAbuse103248958 yago:MajorTranquilizer103713736 yago:Matter100020827 yago:Medicine103740161 yago:PhysicalEntity100001930 yago:PsychotropicAgent104017429 drug yago:Sedative-hypnotic104166841 yago:Sedative104166553 yago:Substance100020090 yago:Tranquilizer104470232 yago:Tricyclic104482543
rdfs:label	Fluotracen (en) Fluotraceno (pt)
rdfs:comment	Fluotracen (SKF-28,175) is a tricyclic drug which possesses dual antidepressant and antipsychotic activity. This profile of effects is similar to that of related agents like amoxapine, loxapine, and trimipramine which may also be used in the treatment of both depression and psychosis. It was believed that such duality would be advantageous in the treatment of schizophrenia, as depression is often comorbid with the disorder and usual antipsychotics often worsen such symptoms. In any case, however, fluotracen was never marketed. (en) Fluotraceno (SKF-28,175) é um fármaco com estrutura tricíclica que possui efeitos antidepressivos e antipsicóticos. Possui um perfil farmacológico semelhante aos antidepressivos tricíclicos trimipramina e amoxapina, que também podem ser usados para o tratamento tanto da depressão e a psicose. Acredita-se que tal dualidade seria vantajosa no tratamento da esquizofrenia, já que a depressão está frequentemente em comorbidade com a esquizofrenia (isto é, seus sintomas negativos), e os antipsicóticos podem piorar tais sintomas. No entanto, o fluotraceno nunca foi comercializado. (pt)
foaf:depiction
dcterms:subject	Anthracenes Dimethylamino compounds Trifluoromethyl compounds Tricyclic antidepressants Antipsychotics
Wikipage page ID	27109167 (xsd:integer)
Wikipage revision ID	1119924313 (xsd:integer)
Link from a Wikipage to another Wikipage	Psychosis Schizophrenia Mouth Litracen Anthracenes Dimethylamino compounds Trifluoromethyl compounds Melitracen Antidepressant Antipsychotic Loxapine Major depression Tricyclic antidepressants Trimipramine Drug Amoxapine Antipsychotics Hydrochloride Tricyclic
sameAs	Fluotracen Fluotracen Fluotracen Fluotracen Fluotracen Fluotracen Fluotracen Fluotracen
dbp:wikiPageUsesTemplate	dbt:Antipsychotics dbt:Tricyclics dbt:Adrenergics dbt:Dopaminergics dbt:Drugbox dbt:Reflist dbt:Serotonergics dbt:Short_description dbt:Fdacite dbt:Histaminergics dbt:Antidepressants dbt:Anxiolytics dbt:Cholinergics
thumbnail	wiki-commons:Special:FilePath/Fluotracen.png?width=300
alt	Ball-and-stick model of the fluotracen molecule (en) Skeletal formula of fluotracen (en)
ATC prefix	none (en)
c	21 (xsd:integer)
CAS number	35764 (xsd:integer)
CAS supplemental	57363 (xsd:integer)
ChemSpiderID	38565 (xsd:integer)
F	3 (xsd:integer)
H	24 (xsd:integer)
image	Fluotracen-3D-balls.png (en)
IUPAC name	N,N-dimethyl-3-[10-methyl-2--9,10-dihydroanthracen-9-yl]propan-1-amine (en)
legal status	Uncontrolled (en)
n	1 (xsd:integer)
PubChem	42291 (xsd:integer)
routes of administration	Mouth
SMILES	FCc1ccc3cCCCCNC (en)
UNII	3026 (xsd:integer)
width	210 (xsd:integer)
has abstract	Fluotracen (SKF-28,175) is a tricyclic drug which possesses dual antidepressant and antipsychotic activity. This profile of effects is similar to that of related agents like amoxapine, loxapine, and trimipramine which may also be used in the treatment of both depression and psychosis. It was believed that such duality would be advantageous in the treatment of schizophrenia, as depression is often comorbid with the disorder and usual antipsychotics often worsen such symptoms. In any case, however, fluotracen was never marketed. (en) Fluotraceno (SKF-28,175) é um fármaco com estrutura tricíclica que possui efeitos antidepressivos e antipsicóticos. Possui um perfil farmacológico semelhante aos antidepressivos tricíclicos trimipramina e amoxapina, que também podem ser usados para o tratamento tanto da depressão e a psicose. Acredita-se que tal dualidade seria vantajosa no tratamento da esquizofrenia, já que a depressão está frequentemente em comorbidade com a esquizofrenia (isto é, seus sintomas negativos), e os antipsicóticos podem piorar tais sintomas. No entanto, o fluotraceno nunca foi comercializado. (pt)
gold:hypernym	Drug
prov:wasDerivedFrom	wikipedia-en:Fluotracen?oldid=1119924313&ns=0
page length (characters) of wiki page	2887 (xsd:nonNegativeInteger)
CAS number	35764-73-9

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