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About: FYVE domain     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatProteinDomains, within Data Space : dbpedia.org associated with source document(s)

Type: ThingBiomoleculeBiomoleculeProteinyago:Abstraction100002137yago:Attribute100024264yago:Chemical114806838yago:Compound114818238yago:Environment113934596yago:Macromolecule114944888yago:Material114580897yago:Matter100020827yago:Molecule114682133yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:Protein114728724yago:Relation100031921proteinyago:Situation113927383yago:Sphere114514039yago:State100024720yago:Substance100019613yago:Thing100002452yago:Unit109465459yago:WikicatPeripheralMembraneProteinsyago:WikicatProteinDomains New Facet based on Instances of this Class

In molecular biology the FYVE zinc finger domain is named after the four cysteine-rich proteins: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1, in which it has been found. FYVE domains bind phosphatidylinositol 3-phosphate, in a way dependent on its metal ion coordination and basic amino acids. The FYVE domain inserts into cell membranes in a pH-dependent manner. The FYVE domain has been connected to vacuolar protein sorting and endosome function.