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About: Ethyl loflazepate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : umbel-rc:DrugProduct, within Data Space : dbpedia.org associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceDrugyago:WikicatBenzodiazepinesyago:Agent114778436yago:Benzodiazepine102830852yago:CausalAgent100007347yago:Drug103247620yago:DrugOfAbuse103248958yago:Hypnagogue114913744yago:Matter100020827yago:Medicine103740161yago:MinorTranquilizer103771443yago:MuscleRelaxant103800001yago:PhysicalEntity100001930yago:PsychotropicAgent104017429yago:Relaxant104072811yago:WikicatHypnoticsdrugyago:Sedative-hypnotic104166841yago:Sedative104166553yago:Soporific104260934yago:Substance100020090yago:Tranquilizer104470232umbel-rc:DrugProduct New Facet based on Instances of this Class

Ethyl loflazepate (marketed under the brand names Meilax, Ronlax and Victan) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. In animal studies it was found to have low toxicity, although in rats evidence of pulmonary phospholipidosis occurred with pulmonary foam cells developing with long-term use of very high doses. Its elimination half-life is 51–103 hours. Its mechanism of action is similar to other benzodiazepines. Ethyl loflazepate also produces an active metabolite which is stronger than the parent compound. Ethyl loflazepate was designed to be a prodrug for descarboxyloflazepate, its active metabolite. It is the active metabolite which is responsible for most of the pharmacological effects rat