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Eseroline is a drug which acts as an opioid agonist. It is a metabolite of the acetylcholinesterase inhibitor physostigmine but unlike physostigmine, the acetylcholinesterase inhibition produced by eseroline is weak and easily reversible, and it produces fairly potent analgesic effects mediated through the μ-opioid receptor. This mixture of activities gives eseroline an unusual pharmacological profile, although its uses are limited by side effects such as respiratory depression and neurotoxicity.

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rdf:type
rdfs:label
  • Eseroline (en)
  • エセロリン (ja)
rdfs:comment
  • Eseroline is a drug which acts as an opioid agonist. It is a metabolite of the acetylcholinesterase inhibitor physostigmine but unlike physostigmine, the acetylcholinesterase inhibition produced by eseroline is weak and easily reversible, and it produces fairly potent analgesic effects mediated through the μ-opioid receptor. This mixture of activities gives eseroline an unusual pharmacological profile, although its uses are limited by side effects such as respiratory depression and neurotoxicity. (en)
  • エセロリン(Eseroline)は、オピオイドアゴニストとして作用する薬剤である。アセチルコリンエステラーゼ阻害剤フィゾスチグミンの代謝物質であるが、フィゾスチグミンとは異なり、アセチルコリンエステラーゼ阻害作用は弱く、容易に逆行し、に媒介されるかなり強い鎮痛剤効果を示す。この混合型の活性のため、エセロリンの薬理作用のプロファイルはかなり独特なものとなるが、や神経毒性等の副作用のため、利用は限られている。 (ja)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/Eseroline_molecule_ball.png
  • http://commons.wikimedia.org/wiki/Special:FilePath/Eseroline_skeletal.svg
dcterms:subject
Wikipage page ID
Wikipage revision ID
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alt
  • Ball-and-stick model (en)
  • Skeletal formula (en)
ATC prefix
  • none (en)
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CAS number
ChEBI
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image
  • Eseroline molecule ball.png (en)
IUPAC name
n
O
PubChem
SMILES
  • C[C@@]12CCNC (en)
StdInChI
StdInChIKey
  • HKGWQUVGHPDEBZ-OLZOCXBDSA-N (en)
synonyms
  • Eseroline (en)
UNII
  • Q22H41O18D (en)
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has abstract
  • Eseroline is a drug which acts as an opioid agonist. It is a metabolite of the acetylcholinesterase inhibitor physostigmine but unlike physostigmine, the acetylcholinesterase inhibition produced by eseroline is weak and easily reversible, and it produces fairly potent analgesic effects mediated through the μ-opioid receptor. This mixture of activities gives eseroline an unusual pharmacological profile, although its uses are limited by side effects such as respiratory depression and neurotoxicity. (en)
  • エセロリン(Eseroline)は、オピオイドアゴニストとして作用する薬剤である。アセチルコリンエステラーゼ阻害剤フィゾスチグミンの代謝物質であるが、フィゾスチグミンとは異なり、アセチルコリンエステラーゼ阻害作用は弱く、容易に逆行し、に媒介されるかなり強い鎮痛剤効果を示す。この混合型の活性のため、エセロリンの薬理作用のプロファイルはかなり独特なものとなるが、や神経毒性等の副作用のため、利用は限られている。 (ja)
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page length (characters) of wiki page
CAS number
  • 469-22-7
ChEBI
  • 48845
FDA UNII code
  • Q22H41O18D
PubChem
  • 119198
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