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Doxefazepam (marketed under brand name Doxans) is a benzodiazepine medication It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is used therapeutically as a hypnotic. According to Babbini and colleagues in 1975, this derivative of flurazepam was between 2 and 4 times more potent than the latter while at the same time being half as toxic in laboratory animals. It was patented in 1972 and came into medical use in 1984.

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  • دوكسيفازيبام (ar)
  • Doxefazepam (en)
  • Doxefazepam (it)
  • Doxefazepam (pt)
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  • دوكسيفازيبام هو دواء ينتمي لفئة البنزوديازيبينات له خصائص مزيلة للقلق، ومضادة للاختلاج، ومهدئة، ومرخية للعضلات الهيكلية، لذا يُستخدم علاجيًا كمنوم. سُجّلت براءة اختراع مركب دوكسيفازيبام في عام 1972، وبدأ استخدامه في التطبيقات الطبية كعلاج في عام 1984. اشتقّ مركّب الدوكسيفازيبام من مركب الفلورازيبام في عام 1975، ووُجد أنّ مفعوله أقوى بمقدار مرتين إلى 4 مرات من ركب الفلورازيبام، وفي نفس الوقت أقل سمّية بمقدار النصف في حيوانات المختبر. (ar)
  • Doxefazepam (marketed under brand name Doxans) is a benzodiazepine medication It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties. It is used therapeutically as a hypnotic. According to Babbini and colleagues in 1975, this derivative of flurazepam was between 2 and 4 times more potent than the latter while at the same time being half as toxic in laboratory animals. It was patented in 1972 and came into medical use in 1984. (en)
  • Il doxefazepam è un farmaco benzodiazepinico con attività farmacologica simile a quella del diazepam. La sostanza fu sviluppata negli anni '70 dalla società farmacologica Schiapparelli.In un lavoro scientifico sui ratti risalente al 1990 è stata segnalata una tendenza significativa a sviluppare neoplasie benigne epatocellulari. Nel medesimo studio è stata riscontrata una incidenza lievemente superiore di gliomi maligni (in particolare oligodendrogliomi), ma i risultati non erano di significatività statistica. (it)
  • Doxefazepam (comercializado sob a marca Doxans) é um medicamento benzodiazepínico. Possui propriedades ansiolíticas, anticonvulsivantes, sedativas e relaxantes musculoesqueléticas. É usado terapeuticamente como um hipnótico. De acordo com Babbini et al, em 1975, esse derivado do flurazepam era 2 a 4 vezes mais potente do que o último, e ao mesmo tempo possuía metade da toxicidade em animais de laboratório. Foi patenteado em 1972 e entrou em uso médico em 1984. (pt)
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