Don't Give Up on Us is a 2006 Filipino romantic comedy film directed by Joyce E. Bernal. The film was the fifth and last screen appearance of Judy Ann Santos and Piolo Pascual together (after Esperanza: The Movie, Kahit Isang Saglit, Bakit 'Di Totohanin and Till There Was You) prior to the premiering of Sa Piling Mo next month as well as the non-official entry for the 31st Metro Manila Film Festival almost 3 weeks later. The Cinema Evaluation Board (CEB) gave Don't Give Up on Us a B rating, which made it eligible for a 65% tax rebate on its earnings in the Philippines.