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About: dbr:Dihydrofolate_reductase     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatProteinDomains, within Data Space : dbpedia.org associated with source document(s)

Type: ThingBiomoleculeBiomoleculeEnzymeyago:Abstraction100002137yago:Activator114723079yago:Attribute100024264yago:Catalyst114723628yago:Chemical114806838yago:Compound114818238yago:Environment113934596yago:Enzyme114732946yago:Macromolecule114944888yago:Material114580897yago:Matter100020827yago:Molecule114682133yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:Protein114728724yago:Relation100031921yago:WikicatHumanProteinsenzymeproteinyago:Situation113927383yago:Sphere114514039yago:State100024720yago:Substance100019613yago:Thing100002452yago:Unit109465459yago:WikicatEnzymesyago:WikicatProteinDomains New Facet based on Instances of this Class

Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as an electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene.It is found in the q11→q22 region of chromosome 5. Bacterial species possess distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar.