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Dihydroceramide desaturase is the enzyme involved in the conversion of into ceramide by inserting the 4,5-trans-double bond to the sphingolipid backbone of dihydroceramide. DDase require the O2 and the NAD(P)H as cofactor. The activity of DDase is influenced by several factors as N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11), is the inhibitor DDase activity.

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  • Dihydroceramide desaturase (en)
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  • Dihydroceramide desaturase is the enzyme involved in the conversion of into ceramide by inserting the 4,5-trans-double bond to the sphingolipid backbone of dihydroceramide. DDase require the O2 and the NAD(P)H as cofactor. The activity of DDase is influenced by several factors as N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11), is the inhibitor DDase activity. (en)
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  • Dihydroceramide desaturase (en)
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  • Dihydroceramide desaturase (en)
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  • Dihydroceramide desaturase is the enzyme involved in the conversion of into ceramide by inserting the 4,5-trans-double bond to the sphingolipid backbone of dihydroceramide. DDase require the O2 and the NAD(P)H as cofactor. The activity of DDase is influenced by several factors as 1. * alkyl chain length of the sphingoid base (in the order C18 > C12 > C8) and fatty acid (C8 > C18) 2. * The stereochemistry of the sphingoid base (D-erythro- > L-threo-dihydroceramides) 3. * the nature of the headgroup, with the highest activity with dihydroceramide, but some (approximately 20%) activity with dihydroglucosylceramide 4. * The ability to utilize alternative reductants like ascorbic acid could substitute for a reduced pyridine nucleotide, but it act as inhibitory at higher concentrations. N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11), is the inhibitor DDase activity. (en)
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  • 1.14.19.17
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