About: DUTP diphosphatase

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In Enzymology, a dUTP diphosphatase (EC 3.6.1.23) is an enzyme that catalyzes the chemical reaction dUTP + H2O dUMP + diphosphate Thus, the two substrates of this enzyme are and H2O, whereas its two products are dUMP and diphosphate.

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Enzyme yago:Abstraction100002137 yago:Family108078020 yago:Group100031264 yago:Organization108008335 yago:YagoLegalActor yago:YagoLegalActorGeo yago:YagoPermanentlyLocatedEntity enzyme yago:SocialGroup107950920 yago:Unit108189659
rdfs:label	DUTP diphosphatase (en)
rdfs:comment	In Enzymology, a dUTP diphosphatase (EC 3.6.1.23) is an enzyme that catalyzes the chemical reaction dUTP + H2O dUMP + diphosphate Thus, the two substrates of this enzyme are and H2O, whereas its two products are dUMP and diphosphate. (en)
foaf:name	dUTP diphosphatase (en)
name	dUTP diphosphatase (en) dUTPase (en) dUTPase_2 (en)
foaf:depiction
dcterms:subject	Enzymes of known structure EC 3.6.1
Wikipage page ID	14440452 (xsd:integer)
Wikipage revision ID	1085482255 (xsd:integer)
Link from a Wikipage to another Wikipage	List of enzymes Nucleotide Homo sapiens Beta sheet DNA DNA polymerase Enzymology Enzymes of known structure Chemical reaction Pyrimidine metabolism Enzyme Enzymes Crystal structure Protein Data Bank Protein subunit Substrate (biochemistry) DnaS DUT (gene) Escherichia coli Protein folding Product (chemistry) EC 3.6.1 Hydrolase Tertiary structure DUMP Organism Catalysis Sequence homology Water Secondary structure Diphosphate Trimer (biochemistry) dbr:Deoxyuridine_triphosphate
sameAs	DUTP diphosphatase DUTP diphosphatase DUTP diphosphatase DUTP diphosphatase DUTP diphosphatase DUTP diphosphatase
dbp:wikiPageUsesTemplate	dbt:3.6-enzyme-stub dbt:Cite_journal dbt:EC_number dbt:Enzyme dbt:Enzymes dbt:Infobox_protein_family dbt:InterPro_content dbt:PDB_link dbt:Portal_bar dbt:Reflist dbt:Short_description dbt:Acid_anhydride_hydrolases dbt:Lowercase
thumbnail	wiki-commons:Special:FilePath/PDB_1f7o_EBI.jpg?width=300
SCOP	1 (xsd:integer) 6.31152E7 (second)
caption	crystal structures of feline immunodeficiency virus dutp pyrophosphatase and its nucleotide complexes in three crystal forms. (en) the crystal structure of a complex of campylobacter jejuni dutpase with substrate analogue dupnhp (en)
CAS number	37289 (xsd:integer)
EC number	3.600000 (xsd:double)
GO code	4170 (xsd:integer)
InterPro	IPR008180 (en) IPR014871 (en)
IUBMB EC number	3 (xsd:integer)
Pfam	PF00692 (en) PF08761 (en)
Pfam clan	CL0153 (en) CL0231 (en)
symbol	dUTPase (en) dUTPase_2 (en)
has abstract	In Enzymology, a dUTP diphosphatase (EC 3.6.1.23) is an enzyme that catalyzes the chemical reaction dUTP + H2O dUMP + diphosphate Thus, the two substrates of this enzyme are and H2O, whereas its two products are dUMP and diphosphate. This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dUTP nucleotidohydrolase. Other names in common use include deoxyuridine-triphosphatase, dUTPase, dUTP pyrophosphatase, desoxyuridine 5'-triphosphate nucleotidohydrolase, and desoxyuridine 5'-triphosphatase. This enzyme participates in pyrimidine metabolism. This enzyme has a dual function: on one hand, it removes dUTP from the deoxynucleotide pool, which reduces the probability of this base being incorporated into DNA by DNA polymerases, while on the other hand, it produces the dTTP precursor dUMP. Lack or inhibition of dUTPase action leads to harmful perturbations in the nucleotide pool resulting in increased uracil content of DNA that activates a hyperactive futile cycle of DNA repair. (en)
prov:wasDerivedFrom	wikipedia-en:DUTP_diphosphatase?oldid=1085482255&ns=0
page length (characters) of wiki page	7453 (xsd:nonNegativeInteger)
EC number	3.6.1.23
foaf:isPrimaryTopicOf	wikipedia-en:DUTP_diphosphatase

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