About: DNA polymerase alpha

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DNA polymerase alpha also known as Pol α is an enzyme complex found in eukaryotes that is involved in initiation of DNA replication. The DNA polymerase alpha complex consists of 4 subunits: POLA1, POLA2, PRIM1, and PRIM2.

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Enzyme building enzyme
rdfs:label	DNA polymerase alpha (en)
rdfs:comment	DNA polymerase alpha also known as Pol α is an enzyme complex found in eukaryotes that is involved in initiation of DNA replication. The DNA polymerase alpha complex consists of 4 subunits: POLA1, POLA2, PRIM1, and PRIM2. (en)
foaf:name	DNA-directed DNA polymerase (en)
name	DNA-directed DNA polymerase (en)
dcterms:subject	EC 2.7.7 DNA replication DNA-binding proteins
Wikipage page ID	44593240 (xsd:integer)
Wikipage revision ID	1099916609 (xsd:integer)
Link from a Wikipage to another Wikipage	Processivity DNA polymerase delta DNA replication EC 2.7.7 Enzyme Eukaryote DNA replication DNA-binding proteins PRIM2 DNA primase Exonuclease PRIM1 Okazaki fragment POLA1 POLA2 Electron transport dbr:File:Shared_primase-binding_peptide_in_archaeal_PolD_and_eukaryotic_Polα.pdf
sameAs	DNA polymerase alpha DNA polymerase alpha DNA polymerase alpha DNA polymerase alpha DNA polymerase alpha
dbp:wikiPageUsesTemplate	dbt:2.7-enzyme-stub dbt:Enzymes dbt:Infobox_enzyme dbt:Kinases dbt:MeshName dbt:Portal_bar dbt:Reflist dbt:Short_description dbt:NLM_content dbt:DNA_replication
CAS number	9012 (xsd:integer)
EC number	2.700000 (xsd:double)
IUBMB EC number	2 (xsd:integer)
has abstract	DNA polymerase alpha also known as Pol α is an enzyme complex found in eukaryotes that is involved in initiation of DNA replication. The DNA polymerase alpha complex consists of 4 subunits: POLA1, POLA2, PRIM1, and PRIM2. Pol α has limited processivity and lacks 3′ exonuclease activity for proofreading errors. Thus it is not well suited to efficiently and accurately copy long templates (unlike Pol Delta and Epsilon). Instead it plays a more limited role in replication. Pol α is responsible for the initiation of DNA replication at origins of replication (on both the leading and lagging strands) and during synthesis of Okazaki fragments on the lagging strand. The Pol α complex (pol α-DNA primase complex) consists of four subunits: the catalytic subunit POLA1, the regulatory subunit POLA2, and the small and the large primase subunits PRIM1 and PRIM2 respectively. Once primase has created the RNA primer, Pol α starts replication elongating the primer with ~20 nucleotides. (en)
gold:hypernym	Complex
prov:wasDerivedFrom	wikipedia-en:DNA_polymerase_alpha?oldid=1099916609&ns=0
page length (characters) of wiki page	3183 (xsd:nonNegativeInteger)
EC number	2.7.7.7
foaf:isPrimaryTopicOf	wikipedia-en:DNA_polymerase_alpha
is Link from a Wikipage to another Wikipage of	Processivity DNA polymerase DNA replication Induced cell cycle arrest Prunus × yedoensis dbr:Aphidicolin DNA pol alpha DNA polymerase (disambiguation) DNA polymerase alpha subunit 2 Cell synchronization PRIM2 DNA Polymerase α DNA polymerase α Polymerase POLA1 (gene) Polymerase (DNA directed), alpha 1
is Wikipage redirect of	DNA pol alpha DNA Polymerase α DNA polymerase α POLA1 (gene) Polymerase (DNA directed), alpha 1
is foaf:primaryTopic of	wikipedia-en:DNA_polymerase_alpha

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